Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs JE Phelan, DM O’sullivan, D Machado, J Ramos, YEA Oppong, ... Genome medicine 11, 1-7, 2019 | 326 | 2019 |
Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis D Machado, I Couto, J Perdigao, L Rodrigues, I Portugal, P Baptista, ... PloS one 7 (4), e34538, 2012 | 299 | 2012 |
Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex L Rodrigues, D Machado, I Couto, L Amaral, M Viveiros Infection, Genetics and Evolution 12 (4), 695-700, 2012 | 177 | 2012 |
High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations D Machado, J Perdigao, J Ramos, I Couto, I Portugal, C Ritter, ... Journal of Antimicrobial Chemotherapy 68 (8), 1728-1732, 2013 | 160 | 2013 |
Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus SS Costa, C Falcão, M Viveiros, D Machado, M Martins, J Melo-Cristino, ... BMC microbiology 11, 1-12, 2011 | 132 | 2011 |
Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study E Cambau, M Viveiros, D Machado, L Raskine, C Ritter, E Tortoli, ... Journal of Antimicrobial Chemotherapy 70 (3), 686-696, 2015 | 125 | 2015 |
Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs M Viveiros, M Martins, L Rodrigues, D Machado, I Couto, J Ainsa, ... Expert review of anti-infective therapy 10 (9), 983-998, 2012 | 125 | 2012 |
Challenging the drug-likeness dogma for new drug discovery in tuberculosis D Machado, M Girardini, M Viveiros, M Pieroni Frontiers in microbiology 9, 1367, 2018 | 111 | 2018 |
Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil T Coelho, D Machado, I Couto, R Maschmann, D Ramos, A von Groll, ... Frontiers in microbiology 6, 330, 2015 | 106 | 2015 |
Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis B Veigas, D Machado, J Perdigao, I Portugal, I Couto, M Viveiros, ... Nanotechnology 21 (41), 415101, 2010 | 103 | 2010 |
Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis D Machado, D Pires, J Perdigao, I Couto, I Portugal, M Martins, L Amaral, ... PloS one 11 (2), e0149326, 2016 | 102 | 2016 |
Antimicrobial susceptibility testing of Mycobacterium tuberculosis complex isolates–the EUCAST broth microdilution reference method for MIC determination T Schön, J Werngren, D Machado, E Borroni, M Wijkander, G Lina, ... Clinical Microbiology and Infection 26 (11), 1488-1492, 2020 | 96 | 2020 |
Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis D Machado, TS Coelho, J Perdigao, C Pereira, I Couto, I Portugal, ... Frontiers in microbiology 8, 711, 2017 | 92 | 2017 |
Geographic distribution of nontuberculous mycobacteria isolated from clinical specimens: a systematic review SMH Zweijpfenning, J van Ingen, W Hoefsloot Seminars in respiratory and critical care medicine 39 (03), 336-342, 2018 | 86 | 2018 |
Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting J Perdigão, H Silva, D Machado, R Macedo, F Maltez, C Silva, L Jordao, ... BMC genomics 15, 1-20, 2014 | 84 | 2014 |
The role of efflux pumps in macrolide resistance in Mycobacterium avium complex L Rodrigues, D Sampaio, I Couto, D Machado, WV Kern, L Amaral, ... International journal of antimicrobial agents 34 (6), 529-533, 2009 | 84 | 2009 |
HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality AM Tavares, I Fronteira, I Couto, D Machado, M Viveiros, AB Abecasis, ... PloS one 12 (9), e0185526, 2017 | 83 | 2017 |
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery E Azzali, D Machado, A Kaushik, F Vacondio, S Flisi, CS Cabassi, ... Journal of medicinal chemistry 60 (16), 7108-7122, 2017 | 76 | 2017 |
Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs. Genome Med 11: 41 JE Phelan, DM O’sullivan, D Machado, J Ramos, YEA Oppong, ... DOI: https://doi. org/10.1186/s13073-019-0650-x. PMID: https://www. ncbi …, 2019 | 74 | 2019 |
The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction AR Costa, SC Sousa, R Pinto-Costa, JC Mateus, CDF Lopes, AC Costa, ... Elife 9, e55471, 2020 | 73 | 2020 |