David E. Gloriam

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Alexander Sebastian HauserUniversity of CopenhagenVerified email at alumni.ku.dk
Kasper HarpsøeDepartment of Drug Design and Pharmacology, University of CopenhagenVerified email at sund.ku.dk
Hans Bräuner-OsborneProfessor of Molecular Pharmacology, University of CopenhagenVerified email at sund.ku.dk
Helgi SchiöthProfessor at Department of Neuroscience, Functional Pharmacology, Uppsala UniversityVerified email at neuro.uu.se
Vignir IsbergSenior Manager, NovonesisVerified email at vignir.org
Robert FredrikssonUppsala UniversityVerified email at neuro.uu.se
Christian MunkNovozymesVerified email at sund.ku.dk
Albert J. KooistraUniversity of Copenhagen | Synamics Tx | KvantifyVerified email at sund.ku.dk
M. Madan BabuMember and Endowed Chair, St Jude Children's Research Hospital, USAVerified email at stjude.org
Andrzej BojarskiMaj Institute of Pharmacology Polish Academy of SciencesVerified email at if-pan.krakow.pl
Vriend GDirector BIPS Mindoro PhilippinesVerified email at radboudumc.nl
Petrine WellendorphUniversity of CopenhagenVerified email at sund.ku.dk
Daniel Sejer PedersenChemical Development Specialist at Novo NordiskVerified email at novonordisk.com
Krzysztof RatajArdigen S.AVerified email at ardigen.com
Par J. HoglundKarolinska Institute & Jönköping Academy for Improvement of Health And WelfareVerified email at ki.se
Patrik RydbergAssociate Director, Computational Chemmistry, Optibrium Ltd.Verified email at optibrium.com
Kirill MartemyanovProfessor, The Scripps Research InstituteVerified email at scripps.edu
Peter KolbPhilipps-University MarburgVerified email at uni-marburg.de
Mathias Rask-AndersenDept. of Neuroscience, Uppsala UniversityVerified email at neuro.uu.se
Misty M AttwoodDepartment of Neuroscience, Uppsala UniversityVerified email at neuro.uu.se

David E. Gloriam

Department of Drug Design and Pharmacology, University of Copenhagen

Verified email at sund.ku.dk - Homepage

GPCRs Computational drug design scientific database development structural biology


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Trends in GPCR drug discovery: new agents, targets and indications AS Hauser, MM Attwood, M Rask-Andersen, HB Schiöth, DE Gloriam Nature reviews Drug discovery 16 (12), 829-842, 2017	2566	2017
Pharmacogenomics of GPCR drug targets AS Hauser, S Chavali, I Masuho, LJ Jahn, KA Martemyanov, DE Gloriam, ... Cell 172 (1), 41-54. e19, 2018	662	2018
Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse TK Bjarnadóttir, DE Gloriam, SH Hellstrand, H Kristiansson, R Fredriksson, ... Genomics 88 (3), 263-273, 2006	581	2006
GPCRdb in 2018: adding GPCR structure models and ligands G Pándy-Szekeres, C Munk, TM Tsonkov, S Mordalski, K Harpsøe, ... Nucleic acids research 46 (D1), D440-D446, 2018	575	2018
Generic GPCR residue numbers–aligning topology maps while minding the gaps V Isberg, C De Graaf, A Bortolato, V Cherezov, V Katritch, FH Marshall, ... Trends in pharmacological sciences 36 (1), 22-31, 2015	483	2015
GPCRdb: an information system for G protein-coupled receptors V Isberg, S Mordalski, C Munk, K Rataj, K Harpsøe, AS Hauser, B Vroling, ... Nucleic acids research 44 (D1), D356-D364, 2016	473	2016
Selectivity determinants of GPCR–G-protein binding T Flock, AS Hauser, N Lund, DE Gloriam, S Balaji, MM Babu Nature 545 (7654), 317-322, 2017	402	2017
Seven evolutionarily conserved human rhodopsin G protein‐coupled receptors lacking close relatives R Fredriksson, PJ Höglund, DEI Gloriam, MC Lagerström, HB Schiöth FEBS letters 554 (3), 381-388, 2003	381	2003
GPCRdb in 2021: integrating GPCR sequence, structure and function AJ Kooistra, S Mordalski, G Pándy-Szekeres, M Esguerra, A Mamyrbekov, ... Nucleic Acids Research 49 (D1), D335-D343, 2021	355	2021
SMARTCyp: a 2D method for prediction of cytochrome P450-mediated drug metabolism P Rydberg, DE Gloriam, J Zaretzki, C Breneman, L Olsen ACS medicinal chemistry letters 1 (3), 96-100, 2010	321	2010
The human and mouse repertoire of the adhesion family of G-protein-coupled receptors TK Bjarnadóttir, R Fredriksson, PJ Höglund, DE Gloriam, MC Lagerström, ... Genomics 84 (1), 23-33, 2004	321	2004
The G protein-coupled receptor subset of the rat genome DE Gloriam, R Fredriksson, HB Schiöth BMC genomics 8, 1-17, 2007	264	2007
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome MJ Taussig, O Stoevesandt, CAK Borrebaeck, AR Bradbury, D Cahill, ... Nature methods 4 (1), 13-17, 2007	259	2007
5-HT2C receptor structures reveal the structural basis of GPCR polypharmacology Y Peng, JD McCorvy, K Harpsøe, K Lansu, S Yuan, P Popov, L Qu, M Pu, ... Cell 172 (4), 719-730. e14, 2018	245	2018
GPCRdb: the G protein‐coupled receptor database–an introduction C Munk, V Isberg, S Mordalski, K Harpsøe, K Rataj, AS Hauser, P Kolb, ... British Journal of Pharmacology 173 (14), 2195-2207, 2016	241	2016
Discovery of human signaling systems: pairing peptides to G protein-coupled receptors SR Foster, AS Hauser, L Vedel, RT Strachan, XP Huang, AC Gavin, ... Cell 179 (4), 895-908. e21, 2019	216	2019
Structural insights into the lipid and ligand regulation of serotonin receptors P Xu, S Huang, H Zhang, C Mao, XE Zhou, X Cheng, IA Simon, DD Shen, ... Nature 592 (7854), 469-473, 2021	200	2021
GPCR activation mechanisms across classes and macro/microscales AS Hauser, AJ Kooistra, C Munk, FM Heydenreich, DB Veprintsev, ... Nature structural & molecular biology 28 (11), 879-888, 2021	185	2021
The SMARTCyp cytochrome P450 metabolism prediction server P Rydberg, DE Gloriam, L Olsen Bioinformatics 26 (23), 2988-2989, 2010	165	2010
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs C Avet, A Mancini, B Breton, C Le Gouill, AS Hauser, C Normand, ... Elife 11, e74101, 2022	161	2022

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