Mads Gyrd-Hansen
Mads Gyrd-Hansen
LEO Foundation Skin Immunology Research Center, University of Copenhagen
Verified email at - Homepage
Cited by
Cited by
IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
M Gyrd-Hansen, P Meier
Nature Reviews Cancer 10 (8), 561-574, 2010
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization
J Nylandsted, M Gyrd-Hansen, A Danielewicz, N Fehrenbacher, ...
The Journal of experimental medicine 200 (4), 425-435, 2004
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin
K Keusekotten, PR Elliott, L Glockner, BK Fiil, RB Damgaard, Y Kulathu, ...
Cell 153 (6), 1312-1326, 2013
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity
RB Damgaard, U Nachbur, M Yabal, WWL Wong, BK Fiil, M Kastirr, ...
Molecular cell 46 (6), 746-758, 2012
Attenuation of c GAS‐STING signaling is mediated by a p62/SQSTM 1‐dependent autophagy pathway activated by TBK1
T Prabakaran, C Bodda, C Krapp, B Zhang, MH Christensen, C Sun, ...
The EMBO journal 37 (8), e97858, 2018
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis
M Gyrd-Hansen, M Darding, M Miasari, MM Santoro, L Zender, W Xue, ...
Nature cell biology 10 (11), 1309-1317, 2008
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling
BK Fiil, RB Damgaard, SA Wagner, K Keusekotten, M Fritsch, ...
Molecular cell 50 (6), 818-830, 2013
XIAP restricts TNF-and RIP3-dependent cell death and inflammasome activation
M Yabal, N Müller, H Adler, N Knies, CJ Groß, RB Damgaard, ...
Cell reports 7 (6), 1796-1808, 2014
Molecular basis and regulation of OTULIN-LUBAC interaction
PR Elliott, SV Nielsen, P Marco-Casanova, BK Fiil, K Keusekotten, ...
Molecular cell 54 (3), 335-348, 2014
X-linked inhibitor of apoptosis (XIAP) deficiency: the spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis
C Speckmann, K Lehmberg, MH Albert, RB Damgaard, M Fritsch, ...
Clinical immunology 149 (1), 133-141, 2013
Sensitization to the lysosomal cell death pathway upon immortalization and transformation
N Fehrenbacher, M Gyrd-Hansen, B Poulsen, U Felbor, T Kallunki, ...
Cancer research 64 (15), 5301-5310, 2004
Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity
M Gyrd-Hansen, J Nylandsted, M Jäättelä
Cell Cycle 3 (12), 1484-1485, 2004
SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling
PR Elliott, D Leske, M Hrdinka, K Bagola, BK Fiil, SH McLaughlin, ...
Molecular cell 63 (6), 990-1005, 2016
CYLD limits Lys63-and Met1-linked ubiquitin at receptor complexes to regulate innate immune signaling
M Hrdinka, BK Fiil, M Zucca, D Leske, K Bagola, M Yabal, PR Elliott, ...
Cell reports 14 (12), 2846-2858, 2016
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease
T Schwerd, S Pandey, HT Yang, K Bagola, E Jameson, J Jung, ...
Gut 66 (6), 1060-1073, 2017
Disease‐causing mutations in the XIAP BIR 2 domain impair NOD 2‐dependent immune signalling
RB Damgaard, BK Fiil, C Speckmann, M Yabal, U Stadt, S Bekker‐Jensen, ...
EMBO molecular medicine 5 (8), 1278-1295, 2013
The Met1-linked ubiquitin machinery: emerging themes of (De) regulation
M Hrdinka, M Gyrd-Hansen
Molecular cell 68 (2), 265-280, 2017
Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9
M Gyrd-Hansen, T Farkas, N Fehrenbacher, L Bastholm, M Høyer-Hansen, ...
Molecular and cellular biology 26 (21), 7880-7891, 2006
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
U Nachbur, CA Stafford, A Bankovacki, Y Zhan, LM Lindqvist, BK Fiil, ...
Nature communications 6 (1), 6442, 2015
Inflammatory signaling by NOD-RIPK2 is inhibited by clinically relevant type II kinase inhibitors
P Canning, Q Ruan, T Schwerd, M Hrdinka, JL Maki, D Saleh, ...
Chemistry & biology 22 (9), 1174-1184, 2015
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