| Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization JM Casolari, CR Brown, S Komili, J West, H Hieronymus, PA Silver Cell 117 (4), 427-439, 2004 | 688 | 2004 |
| Advanced siRNA designs further improve in vivo performance of GalNAc-siRNA conjugates DJ Foster, CR Brown, S Shaikh, C Trapp, MK Schlegel, K Qian, A Sehgal, ... Molecular Therapy 26 (3), 708-717, 2018 | 260 | 2018 |
| Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates JK Nair, H Attarwala, A Sehgal, Q Wang, K Aluri, X Zhang, M Gao, J Liu, ... Nucleic acids research 45 (19), 10969-10977, 2017 | 232 | 2017 |
| Developmentally induced changes in transcriptional program alter spatial organization across chromosomes JM Casolari, CR Brown, DA Drubin, OJ Rando, PA Silver Genes & development 19 (10), 1188-1198, 2005 | 219 | 2005 |
| Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes CR Brown, CJ Kennedy, VA Delmar, DJ Forbes, PA Silver Genes & development 22 (5), 627-639, 2008 | 207 | 2008 |
| Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates CR Brown, S Gupta, J Qin, T Racie, G He, S Lentini, R Malone, M Yu, ... Nucleic acids research 48 (21), 11827-11844, 2020 | 180 | 2020 |
| Genomic association of the proteasome demonstrates overlapping gene regulatory activity with transcription factor substrates KL Auld, CR Brown, JM Casolari, S Komili, PA Silver Molecular cell 21 (6), 861-871, 2006 | 139 | 2006 |
| Linking stochastic fluctuations in chromatin structure and gene expression CR Brown, C Mao, E Falkovskaia, MS Jurica, H Boeger PLoS biology 11 (8), e1001621, 2013 | 131 | 2013 |
| Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates KM Brown, JK Nair, MM Janas, YI Anglero-Rodriguez, LTH Dang, H Peng, ... Nature biotechnology 40 (10), 1500-1508, 2022 | 122 | 2022 |
| Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling V Beaulieu, N Da Silva, N Pastor-Soler, CR Brown, PJS Smith, D Brown, ... Journal of Biological Chemistry 280 (9), 8452-8463, 2005 | 121 | 2005 |
| Transcriptional regulation at the nuclear pore complex CR Brown, PA Silver Current opinion in genetics & development 17 (2), 100-106, 2007 | 109 | 2007 |
| The prenucleosome, a stable conformational isomer of the nucleosome J Fei, SE Torigoe, CR Brown, MT Khuong, GA Kassavetis, H Boeger, ... Genes & development 29 (24), 2563-2575, 2015 | 79 | 2015 |
| Reversal of siRNA-mediated gene silencing in vivo I Zlatev, A Castoreno, CR Brown, J Qin, S Waldron, MK Schlegel, ... Nature biotechnology 36 (6), 509-511, 2018 | 78 | 2018 |
| siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2 E Elkayam, R Parmar, CR Brown, JL Willoughby, CS Theile, ... Nucleic acids research 45 (6), 3528-3536, 2017 | 76 | 2017 |
| Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates MM Janas, I Zlatev, J Liu, Y Jiang, SA Barros, JE Sutherland, WP Davis, ... Nucleic acids research 47 (7), 3306-3320, 2019 | 70 | 2019 |
| Quantitative analysis of the transcription control mechanism C Mao, CR Brown, E Falkovskaia, S Dong, E Hrabeta‐Robinson, ... Molecular systems biology 6 (1), 431, 2010 | 60 | 2010 |
| Formation and fate of a complete 31-protein RNA polymerase II transcription preinitiation complex K Murakami, G Calero, CR Brown, X Liu, RE Davis, H Boeger, ... Journal of Biological Chemistry 288 (9), 6325-6332, 2013 | 48 | 2013 |
| Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates RG Parmar, CR Brown, S Matsuda, JLS Willoughby, CS Theile, ... Journal of medicinal chemistry 61 (3), 734-744, 2018 | 45 | 2018 |
| The nonclinical disposition and pharmacokinetic/pharmacodynamic properties of N-Acetylgalactosamine–conjugated small interfering RNA are highly predictable and build confidence … R McDougall, D Ramsden, S Agarwal, S Agarwal, K Aluri, M Arciprete, ... Drug Metabolism and Disposition 50 (6), 781-797, 2022 | 44 | 2022 |
| Nucleosomal promoter variation generates gene expression noise CR Brown, H Boeger Proceedings of the National Academy of Sciences 111 (50), 17893-17898, 2014 | 43 | 2014 |
Pamela SilverProfessor of Systems Biology, Harvard Medical SchoolVerified email at hms.harvard.edu
