Christopher R Brown
Christopher R Brown
Korro Bio
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Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization
JM Casolari, CR Brown, S Komili, J West, H Hieronymus, PA Silver
Cell 117 (4), 427-439, 2004
Advanced siRNA designs further improve in vivo performance of GalNAc-siRNA conjugates
DJ Foster, CR Brown, S Shaikh, C Trapp, MK Schlegel, K Qian, A Sehgal, ...
Molecular Therapy 26 (3), 708-717, 2018
Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates
JK Nair, H Attarwala, A Sehgal, Q Wang, K Aluri, X Zhang, M Gao, J Liu, ...
Nucleic acids research 45 (19), 10969-10977, 2017
Developmentally induced changes in transcriptional program alter spatial organization across chromosomes
JM Casolari, CR Brown, DA Drubin, OJ Rando, PA Silver
Genes & development 19 (10), 1188-1198, 2005
Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes
CR Brown, CJ Kennedy, VA Delmar, DJ Forbes, PA Silver
Genes & development 22 (5), 627-639, 2008
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
CR Brown, S Gupta, J Qin, T Racie, G He, S Lentini, R Malone, M Yu, ...
Nucleic acids research 48 (21), 11827-11844, 2020
Genomic association of the proteasome demonstrates overlapping gene regulatory activity with transcription factor substrates
KL Auld, CR Brown, JM Casolari, S Komili, PA Silver
Molecular cell 21 (6), 861-871, 2006
Linking stochastic fluctuations in chromatin structure and gene expression
CR Brown, C Mao, E Falkovskaia, MS Jurica, H Boeger
PLoS biology 11 (8), e1001621, 2013
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
KM Brown, JK Nair, MM Janas, YI Anglero-Rodriguez, LTH Dang, H Peng, ...
Nature biotechnology 40 (10), 1500-1508, 2022
Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling
V Beaulieu, N Da Silva, N Pastor-Soler, CR Brown, PJS Smith, D Brown, ...
Journal of Biological Chemistry 280 (9), 8452-8463, 2005
Transcriptional regulation at the nuclear pore complex
CR Brown, PA Silver
Current opinion in genetics & development 17 (2), 100-106, 2007
The prenucleosome, a stable conformational isomer of the nucleosome
J Fei, SE Torigoe, CR Brown, MT Khuong, GA Kassavetis, H Boeger, ...
Genes & development 29 (24), 2563-2575, 2015
Reversal of siRNA-mediated gene silencing in vivo
I Zlatev, A Castoreno, CR Brown, J Qin, S Waldron, MK Schlegel, ...
Nature biotechnology 36 (6), 509-511, 2018
siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2
E Elkayam, R Parmar, CR Brown, JL Willoughby, CS Theile, ...
Nucleic acids research 45 (6), 3528-3536, 2017
Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
MM Janas, I Zlatev, J Liu, Y Jiang, SA Barros, JE Sutherland, WP Davis, ...
Nucleic acids research 47 (7), 3306-3320, 2019
Quantitative analysis of the transcription control mechanism
C Mao, CR Brown, E Falkovskaia, S Dong, E Hrabeta‐Robinson, ...
Molecular systems biology 6 (1), 431, 2010
Formation and fate of a complete 31-protein RNA polymerase II transcription preinitiation complex
K Murakami, G Calero, CR Brown, X Liu, RE Davis, H Boeger, ...
Journal of Biological Chemistry 288 (9), 6325-6332, 2013
Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates
RG Parmar, CR Brown, S Matsuda, JLS Willoughby, CS Theile, ...
Journal of medicinal chemistry 61 (3), 734-744, 2018
The nonclinical disposition and pharmacokinetic/pharmacodynamic properties of N-Acetylgalactosamine–conjugated small interfering RNA are highly predictable and build confidence …
R McDougall, D Ramsden, S Agarwal, S Agarwal, K Aluri, M Arciprete, ...
Drug Metabolism and Disposition 50 (6), 781-797, 2022
Nucleosomal promoter variation generates gene expression noise
CR Brown, H Boeger
Proceedings of the National Academy of Sciences 111 (50), 17893-17898, 2014
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