Morris F White
Morris F White
Professor of Pediatrics, Harvard Medical School
Verified email at - Homepage
Cited by
Cited by
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance
GS Hotamisligil, P Peraldi, A Budavari, R Ellis, MF White, BM Spiegelman
Science 271 (5249), 665-670, 1996
Disruption of IRS-2 causes type 2 diabetes in mice
DJ Withers, JS Gutierrez, H Towery, DJ Burks, JM Ren, S Previs, Y Zhang, ...
Nature 391 (6670), 900-904, 1998
The insulin signaling system.
MF White, CR Kahn
Journal of biological chemistry 269 (1), 1-4, 1994
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
XJ Sun, P Rothenberg, CR Kahn, JM Backer, E Araki, PA Wilden, ...
Nature 352 (6330), 73-77, 1991
The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307
V Aguirre, T Uchida, L Yenush, R Davis, MF White
Journal of Biological Chemistry 275 (12), 9047-9054, 2000
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
C Yu, Y Chen, GW Cline, D Zhang, H Zong, Y Wang, R Bergeron, JK Kim, ...
Journal of Biological Chemistry 277 (52), 50230-50236, 2002
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, ...
Diabetes 48 (6), 1270-1274, 1999
IRS proteins and the common path to diabetes
MF White
American Journal of Physiology-Endocrinology and Metabolism 283 (3), E413-E422, 2002
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
V Aguirre, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White
Journal of Biological Chemistry 277 (2), 1531-1537, 2002
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
L Rui, M Yuan, D Frantz, S Shoelson, MF White
Journal of Biological Chemistry 277 (44), 42394-42398, 2002
Role of IRS-2 in insulin and cytokine signalling
XJ Sun, LM Wang, Y Zhang, L Yenush, MG Myers Jr, E Glasheen, ...
Nature 377 (6545), 173-177, 1995
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
KD Copps, MF White
Diabetologia 55, 2565-2582, 2012
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
K Morino, KF Petersen, S Dufour, D Befroy, J Frattini, N Shatzkes, ...
The Journal of clinical investigation 115 (12), 3587-3593, 2005
The IRS-signalling system: a network of docking proteins that mediate insulin action
MF White
Insulin Action, 3-11, 1998
Insulin signaling in health and disease
MF White
Science 302 (5651), 1710-1711, 2003
The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
EY Skolnik, CH Lee, A Batzer, LM Vicentini, M Zhou, R Daly, MJ Myers Jr, ...
The EMBO journal 12 (5), 1929-1936, 1993
Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells
MF White, R Maron, CR Kahn
Nature 318 (6042), 183-186, 1985
The insulin signalling system and the IRS proteins
MF White
Diabetologia 40, S2-S17, 1997
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
ZY Jiang, YW Lin, A Clemont, EP Feener, KD Hein, M Igarashi, ...
The Journal of clinical investigation 104 (4), 447-457, 1999
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
DR Kaplan, M Whitman, B Schaffhausen, DC Pallas, M White, L Cantley, ...
Cell 50 (7), 1021-1029, 1987
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