Oscar Fernandez-Capetillo
Oscar Fernandez-Capetillo
Genomic Instability Group, Spanish National Cancer Research Centre (CNIO)
Verified email at - Homepage
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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
SF Bunting, E Callén, N Wong, HT Chen, F Polato, A Gunn, A Bothmer, ...
Cell 141 (2), 243-254, 2010
Genomic instability in mice lacking histone H2AX
A Celeste, S Petersen, PJ Romanienko, O Fernandez-Capetillo, HT Chen, ...
Science 296 (5569), 922-927, 2002
H2AX: the histone guardian of the genome
O Fernandez-Capetillo, A Lee, M Nussenzweig, A Nussenzweig
DNA repair 3 (8-9), 959-967, 2004
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
A Celeste, O Fernandez-Capetillo, MJ Kruhlak, DR Pilch, DW Staudt, ...
Nature cell biology 5 (7), 675-679, 2003
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
RM Marión, K Strati, H Li, M Murga, R Blanco, S Ortega, ...
Nature 460 (7259), 1149-1153, 2009
Replication fork stability confers chemoresistance in BRCA-deficient cells
A Ray Chaudhuri, E Callen, X Ding, E Gogola, AA Duarte, JE Lee, ...
Nature 535 (7612), 382-387, 2016
DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1
O Fernandez-Capetillo, HT Chen, A Celeste, I Ward, PJ Romanienko, ...
Nature cell biology 4 (12), 993-997, 2002
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
D Herranz, M Muñoz-Martin, M Cañamero, F Mulero, B Martinez-Pastor, ...
Nature communications 1 (1), 3, 2010
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility
A Celeste, S Difilippantonio, MJ Difilippantonio, O Fernandez-Capetillo, ...
Cell 114 (3), 371-383, 2003
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis
O Fernandez-Capetillo, SK Mahadevaiah, A Celeste, PJ Romanienko, ...
Developmental cell 4 (4), 497-508, 2003
Silencing of unsynapsed meiotic chromosomes in the mouse
JMA Turner, SK Mahadevaiah, O Fernandez-Capetillo, A Nussenzweig, ...
Nature genetics 37 (1), 41-47, 2005
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks
MJ Kruhlak, A Celeste, G Dellaire, O Fernandez-Capetillo, WG Müller, ...
The Journal of cell biology 172 (6), 823-834, 2006
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
LI Toledo, M Murga, R Zur, R Soria, A Rodriguez, S Martinez, J Oyarzabal, ...
Nature structural & molecular biology 18 (6), 721-727, 2011
Identification of early replicating fragile sites that contribute to genome instability
JH Barlow, RB Faryabi, E Callén, N Wong, A Malhowski, HT Chen, ...
Cell 152 (3), 620-632, 2013
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
P Martínez, M Thanasoula, P Muñoz, C Liao, A Tejera, C McNees, ...
Genes & development 23 (17), 2060-2075, 2009
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
M Murga, S Bunting, MF Montana, R Soria, F Mulero, M Canamero, Y Lee, ...
Nature genetics 41 (8), 891-898, 2009
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
M Murga, S Campaner, AJ Lopez-Contreras, LI Toledo, R Soria, ...
Nature structural & molecular biology 18 (12), 1331-1335, 2011
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
E Callen, M Di Virgilio, MJ Kruhlak, M Nieto-Soler, N Wong, HT Chen, ...
Cell 153 (6), 1266-1280, 2013
ATM regulates ATR chromatin loading in response to DNA double-strand breaks
M Cuadrado, B Martinez-Pastor, M Murga, LI Toledo, P Gutierrez-Martinez, ...
The Journal of experimental medicine 203 (2), 297-303, 2006
p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint
V Lafarga, A Cuadrado, I Lopez de Silanes, R Bengoechea, ...
Molecular and cellular biology 29 (16), 4341-4351, 2009
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