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Roselyne Castonguay
Roselyne Castonguay
Unknown affiliation
Verified email at acceleronpharma.com
Title
Cited by
Cited by
Year
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth
R Castonguay, ED Werner, RG Matthews, E Presman, AW Mulivor, ...
Journal of Biological Chemistry 286 (34), 30034-30046, 2011
2632011
Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb
D Sako, AV Grinberg, J Liu, MV Davies, R Castonguay, S Maniatis, ...
Journal of Biological Chemistry 285 (27), 21037-21048, 2010
2342010
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth
D Mitchell, EG Pobre, AW Mulivor, AV Grinberg, R Castonguay, ...
Molecular cancer therapeutics 9 (2), 379-388, 2010
2112010
Gamma‐glutamyl transpeptidase substrate specificity and catalytic mechanism
JW Keillor, R Castonguay, C Lherbet
Methods in enzymology 401, 449-467, 2005
1282005
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
R Castonguay, W He, AY Chen, C Khosla, DE Cane
Journal of the American Chemical Society 129 (44), 13758-13769, 2007
1012007
Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity
EJ Goebel, RA Corpina, CS Hinck, M Czepnik, R Castonguay, R Grenha, ...
Proceedings of the National Academy of Sciences 116 (31), 15505-15513, 2019
552019
Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase
R Castonguay, CR Valenzano, AY Chen, A Keatinge-Clay, C Khosla, ...
Journal of the American Chemical Society 130 (35), 11598-11599, 2008
552008
Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease
RS Pearsall, MV Davies, M Cannell, J Li, J Widrick, AW Mulivor, S Wallner, ...
Scientific Reports 9 (1), 11392, 2019
452019
Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension
SR Joshi, J Liu, T Bloom, E Karaca Atabay, TH Kuo, M Lee, E Belcheva, ...
Scientific reports 12 (1), 7803, 2022
442022
Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human γ-glutamyltranspeptidase
R Castonguay, D Halim, M Morin, A Furtos, C Lherbet, E Bonneil, ...
Biochemistry 46 (43), 12253-12262, 2007
442007
De novo helical peptides as target sequences for a specific, fluorogenic protein labelling strategy
J Guy, R Castonguay, NBCR Pineda, V Jacquier, K Caron, SW Michnick, ...
Molecular BioSystems 6 (6), 976-987, 2010
412010
Kinetic studies of rat kidney γ-glutamyltranspeptidase deacylation reveal a general base-catalyzed mechanism
R Castonguay, C Lherbet, JW Keillor
Biochemistry 42 (39), 11504-11513, 2003
332003
Nonlinear free energy relationship in the general-acid-catalyzed acylation of rat kidney γ-glutamyl transpeptidase by a series of γ-glutamyl anilide substrate analogues
A Ménard, R Castonguay, C Lherbet, C Rivard, Y Roupioz, JW Keillor
Biochemistry 40 (42), 12678-12685, 2001
322001
TGF-beta superfamily type I and type II receptor heteromultimers and uses thereof
R Kumar, A Grinberg, D Sako, RS Pearsall, R Castonguay
US Patent 10,227,393, 2019
312019
Follistatin-288-Fc fusion protein promotes localized growth of skeletal muscle
R Castonguay, J Lachey, S Wallner, J Strand, K Liharska, AE Watanabe, ...
Journal of Pharmacology and Experimental Therapeutics 368 (3), 435-445, 2019
302019
Pre‐steady‐state kinetic studies of rat kidney γ‐glutamyl transpeptidase confirm its ping‐pong mechanism
JW Keillor, A Menard, R Castonguay, C Lherbet, C Rivard
Journal of physical organic chemistry 17 (6‐7), 529-536, 2004
282004
The orphan ligand, activin C, signals through activin receptor-like kinase 7
EJ Goebel, L Ongaro, EC Kappes, K Vestal, E Belcheva, R Castonguay, ...
Elife 11, e78197, 2022
262022
Mapping of the active site of rat kidney γ-glutamyl transpeptidase using activated esters and their amide derivatives
R Castonguay, C Lherbet, JW Keillor
Bioorganic & medicinal chemistry 10 (12), 4185-4191, 2002
252002
ActRIIB: ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders
J Li, M Fredericks, M Cannell, K Wang, D Sako, MC Maguire, R Grenha, ...
The Journal of clinical investigation 131 (4), 2021
242021
ALK4: ActRIIB heteromultimers and uses thereof
R Kumar, A Grinberg, D Sako, RS Pearsall, R Castonguay
US Patent 10,196,434, 2019
222019
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