Alfred Vertegaal
Alfred Vertegaal
Leiden University Medical Center
Verified email at
Cited by
Cited by
Uncovering global SUMOylation signaling networks in a site-specific manner
IA Hendriks, RCJ D'souza, B Yang, M Verlaan-de Vries, M Mann, ...
Nature structural & molecular biology 21 (10), 927-936, 2014
A comprehensive compilation of SUMO proteomics
IA Hendriks, ACO Vertegaal
Nature reviews Molecular cell biology 17 (9), 581-595, 2016
Distinct and overlapping sets of sumo-1 and sumo-2 target proteins revealed by quantitative proteomics* s
ACO Vertegaal, JS Andersen, SC Ogg, RT Hay, M Mann, AI Lamond
Molecular & Cellular Proteomics 5 (12), 2298-2310, 2006
In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy
I Matic, M van Hagen, J Schimmel, B Macek, SC Ogg, MH Tatham, ...
Molecular & cellular proteomics 7 (1), 132-144, 2008
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation
IA Hendriks, D Lyon, C Young, LJ Jensen, ACO Vertegaal, ML Nielsen
Nature structural & molecular biology 24 (3), 325-336, 2017
Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif
I Matic, J Schimmel, IA Hendriks, MA van Santen, F van de Rijke, ...
Molecular cell 39 (4), 641-652, 2010
SUMOylation-mediated regulation of cell cycle progression and cancer
K Eifler, ACO Vertegaal
Trends in biochemical sciences 40 (12), 779-793, 2015
IκBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase
GJ Schouten, ACO Vertegaal, ST Whiteside, A Israėl, M Toebes, ...
The EMBO journal 16 (11), 3133-3144, 1997
A proteomic study of SUMO-2 target proteins
ACO Vertegaal, SC Ogg, E Jaffray, MS Rodriguez, RT Hay, JS Andersen, ...
Journal of Biological Chemistry 279 (32), 33791-33798, 2004
PARP1 links CHD2-mediated chromatin expansion and H3. 3 deposition to DNA repair by non-homologous end-joining
MS Luijsterburg, I de Krijger, WW Wiegant, RG Shah, G Smeenk, ...
Molecular cell 61 (4), 547-562, 2016
Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein
J Schimmel, K Eifler, JO Siguršsson, SAG Cuijpers, IA Hendriks, ...
Molecular cell 53 (6), 1053-1066, 2014
The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle
J Schimmel, KM Larsen, I Matic, M van Hagen, J Cox, M Mann, ...
Molecular & Cellular Proteomics 7 (11), 2107-2122, 2008
SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.
VAC Hendriks IA, Treffers LW, Verlaan-de Vries M, Olsen JV
Cell Reports 10 (10), 1778–1791, 2015
A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes
MPC Mulder, K Witting, I Berlin, JN Pruneda, KP Wu, JG Chang, R Merkx, ...
Nature chemical biology 12 (7), 523-530, 2016
Signalling mechanisms and cellular functions of SUMO
ACO Vertegaal
Nature Reviews Molecular Cell Biology 23 (11), 715-731, 2022
The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II
Y van der Weegen, H Golan-Berman, TET Mevissen, K Apelt, ...
Nature communications 11 (1), 2104, 2020
The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization
GC Scheper, JL Parra, M Wilson, B Van Kollenburg, ACO Vertegaal, ...
Molecular and cellular biology 23 (16), 5692-5705, 2003
RNF4 is required for DNA double-strand break repair in vivo
R Vyas, R Kumar, F Clermont, A Helfricht, P Kalev, P Sotiropoulou, ...
Cell Death & Differentiation 20 (3), 490-502, 2013
RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α
M van Hagen, RM Overmeer, SS Abolvardi, ACO Vertegaal
Nucleic acids research 38 (6), 1922-1931, 2010
System-wide identification of wild-type SUMO-2 conjugation sites
IA Hendriks, RC D’Souza, JG Chang, M Mann, ACO Vertegaal
Nature communications 6 (1), 7289, 2015
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