Isabelle Becher
Isabelle Becher
EMBL Heidelberg
Verified email at
Cited by
Cited by
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
M Bantscheff, C Hopf, MM Savitski, A Dittmann, P Grandi, AM Michon, ...
Nature biotechnology 29 (3), 255-265, 2011
Systematic analysis of protein turnover in primary cells
T Mathieson, H Franken, J Kosinski, N Kurzawa, N Zinn, G Sweetman, ...
Nature communications 9 (1), 689, 2018
Measuring and managing ratio compression for accurate iTRAQ/TMT quantification
MM Savitski, T Mathieson, N Zinn, G Sweetman, C Doce, I Becher, ...
Journal of proteome research 12 (8), 3586-3598, 2013
High-resolution enabled TMT 8-plexing
T Werner, I Becher, G Sweetman, C Doce, MM Savitski, M Bantscheff
Analytical chemistry 84 (16), 7188-7194, 2012
Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat
I Becher, T Werner, C Doce, EA Zaal, I Tögel, CA Khan, A Rueger, ...
Nature chemical biology 12 (11), 908-910, 2016
Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition
NH Theodoulou, P Bamborough, AJ Bannister, I Becher, RA Bit, KH Che, ...
Journal of medicinal chemistry 59 (4), 1425-1439, 2016
Pervasive protein thermal stability variation during the cell cycle
I Becher, A Andrés-Pons, N Romanov, F Stein, M Schramm, F Baudin, ...
Cell 173 (6), 1495-1507. e18, 2018
Multiplexed proteome dynamics profiling reveals mechanisms controlling protein homeostasis
MM Savitski, N Zinn, M Faelth-Savitski, D Poeckel, S Gade, I Becher, ...
Cell 173 (1), 260-274. e25, 2018
Meltome atlas—thermal proteome stability across the tree of life
A Jarzab, N Kurzawa, T Hopf, M Moerch, J Zecha, N Leijten, Y Bian, ...
Nature methods 17 (5), 495-503, 2020
Thermal proteome profiling for interrogating protein interactions
A Mateus, N Kurzawa, I Becher, S Sridharan, D Helm, F Stein, A Typas, ...
Molecular systems biology 16 (3), e9232, 2020
Identifying drug targets in tissues and whole blood with thermal-shift profiling
J Perrin, T Werner, N Kurzawa, A Rutkowska, DD Childs, M Kalxdorf, ...
Nature Biotechnology 38 (3), 303-308, 2020
Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics
D Helm, JPC Vissers, CJ Hughes, H Hahne, B Ruprecht, F Pachl, A Grzyb, ...
Molecular & Cellular Proteomics 13 (12), 3709-3715, 2014
Functional interdependence of BRD4 and DOT1L in MLL leukemia
O Gilan, EYN Lam, I Becher, D Lugo, E Cannizzaro, G Joberty, A Ward, ...
Nature structural & molecular biology 23 (7), 673-681, 2016
Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP
I Becher, MM Savitski, MF Savitski, C Hopf, M Bantscheff, G Drewes
ACS chemical biology 8 (3), 599-607, 2013
Impact of phosphorylation on thermal stability of proteins
CM Potel, N Kurzawa, I Becher, A Typas, A Mateus, MM Savitski
Nature methods 18 (7), 757-759, 2021
GSK6853, a chemical probe for inhibition of the BRPF1 bromodomain
P Bamborough, HA Barnett, I Becher, MJ Bird, C Chung, PD Craggs, ...
ACS medicinal chemistry letters 7 (6), 552-557, 2016
Cell surface thermal proteome profiling tracks perturbations and drug targets on the plasma membrane
M Kalxdorf, I Günthner, I Becher, N Kurzawa, S Knecht, MM Savitski, ...
Nature Methods 18 (1), 84-91, 2021
Chemoproteomics reveals time-dependent binding of histone deacetylase inhibitors to endogenous repressor complexes
I Becher, A Dittmann, MM Savitski, C Hopf, G Drewes, M Bantscheff
ACS chemical biology 9 (8), 1736-1746, 2014
H-score, a mass accuracy driven rescoring approach for improved peptide identification in modification rich samples
MM Savitski, T Mathieson, I Becher, M Bantscheff
Journal of proteome research 9 (11), 5511-5516, 2010
A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles
N Kurzawa, I Becher, S Sridharan, H Franken, A Mateus, S Anders, ...
Nature communications 11 (1), 5783, 2020
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