David A Bumcrot
David A Bumcrot
Chief Scientific Officer, CAMP4 Therapeutics
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Cited by
Cited by
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
J Soutschek, A Akinc, B Bramlage, K Charisse, R Constien, M Donoghue, ...
Nature 432 (7014), 173-178, 2004
RNAi-mediated gene silencing in non-human primates
TS Zimmermann, ACH Lee, A Akinc, B Bramlage, D Bumcrot, MN Fedoruk, ...
Nature 441 (7089), 111-114, 2006
RNAi therapeutics: a potential new class of pharmaceutical drugs
D Bumcrot, M Manoharan, V Koteliansky, DWY Sah
Nature chemical biology 2 (12), 711-719, 2006
First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement
J Tabernero, GI Shapiro, PM LoRusso, A Cervantes, GK Schwartz, ...
Cancer discovery 3 (4), 406-417, 2013
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
AE Münsterberg, J Kitajewski, DA Bumcrot, AP McMahon, AB Lassar
Genes & development 9 (23), 2911-2922, 1995
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
E Marti, DA Bumcrot, R Takada, AP McMahon
Nature 375 (6529), 322-325, 1995
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
ML Maeder, M Stefanidakis, CJ Wilson, R Baral, LA Barrera, ...
Nature medicine 25 (2), 229-233, 2019
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
M Frank-Kamenetsky, XM Zhang, S Bottega, O Guicherit, H Wichterle, ...
Journal of biology 1, 1-19, 2002
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
E Martí, R Takada, DA Bumcrot, H Sasaki, AP McMahon
Development 121 (8), 2537-2547, 1995
Proteolytic processing yields two secreted forms of sonic hedgehog
DA Bumcrot, R Takada, AP Mcmahon
Molecular and cellular biology 15 (4), 2294-2303, 1995
Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb
Y Yang, G Drossopoulou, PT Chuang, D Duprez, E Marti, D Bumcrot, ...
Development 124 (21), 4393-4404, 1997
Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications
AE Friedland, R Baral, P Singhal, K Loveluck, S Shen, M Sanchez, ...
Genome biology 16, 1-10, 2015
Comparative biological responses to human Sonic, Indian, and Desert hedgehog
S Pathi, S Pagan-Westphal, DP Baker, EA Garber, P Rayhorn, D Bumcrot, ...
Mechanisms of development 106 (1-2), 107-117, 2001
Delivery and specificity of CRISPR/Cas9 genome editing technologies for human gene therapy
JL Gori, PD Hsu, ML Maeder, S Shen, GG Welstead, D Bumcrot
Human gene therapy 26 (7), 443-451, 2015
Compositions and methods for inhibiting expression of Eg5 gene
D Bumcrot, P Tan, HP Vornlocher, A Geick
US Patent 7,718,629, 2010
α-synuclein suppression by targeted small interfering RNA in the primate substantia nigra
AL McCormack, SK Mak, JM Henderson, D Bumcrot, MJ Farrer, ...
PloS one 5 (8), e12122, 2010
MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer
OW Rokhlin, VS Scheinker, AF Taghiyev, D Bumcrot, RA Glover, ...
Cancer biology & therapy 7 (8), 1288-1296, 2008
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia
PJ Schmidt, I Toudjarska, AK Sendamarai, T Racie, S Milstein, ...
Blood, The Journal of the American Society of Hematology 121 (7), 1200-1208, 2013
Compositions and methods for inhibiting expression of Huntingtin gene
DWY Sah, P Hadwiger, I Roehl, B Bramlage, P Tan, HP Vornlocher, ...
US Patent 7,320,965, 2008
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway
M John, R Constien, A Akinc, M Goldberg, YA Moon, M Spranger, ...
Nature 449 (7163), 745-747, 2007
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