| Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs J Soutschek, A Akinc, B Bramlage, K Charisse, R Constien, M Donoghue, ... Nature 432 (7014), 173-178, 2004 | 2952 | 2004 |
| RNAi-mediated gene silencing in non-human primates TS Zimmermann, ACH Lee, A Akinc, B Bramlage, D Bumcrot, MN Fedoruk, ... Nature 441 (7089), 111-114, 2006 | 1864 | 2006 |
| RNAi therapeutics: a potential new class of pharmaceutical drugs D Bumcrot, M Manoharan, V Koteliansky, DWY Sah Nature chemical biology 2 (12), 711-719, 2006 | 1317 | 2006 |
| First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement J Tabernero, GI Shapiro, PM LoRusso, A Cervantes, GK Schwartz, ... Cancer discovery 3 (4), 406-417, 2013 | 766 | 2013 |
| Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. AE Münsterberg, J Kitajewski, DA Bumcrot, AP McMahon, AB Lassar Genes & development 9 (23), 2911-2922, 1995 | 665 | 1995 |
| Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants E Marti, DA Bumcrot, R Takada, AP McMahon Nature 375 (6529), 322-325, 1995 | 637 | 1995 |
| Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10 ML Maeder, M Stefanidakis, CJ Wilson, R Baral, LA Barrera, ... Nature medicine 25 (2), 229-233, 2019 | 616 | 2019 |
| Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists M Frank-Kamenetsky, XM Zhang, S Bottega, O Guicherit, H Wichterle, ... Journal of biology 1, 1-19, 2002 | 592 | 2002 |
| Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo E Martí, R Takada, DA Bumcrot, H Sasaki, AP McMahon Development 121 (8), 2537-2547, 1995 | 507 | 1995 |
| Proteolytic processing yields two secreted forms of sonic hedgehog DA Bumcrot, R Takada, AP Mcmahon Molecular and cellular biology 15 (4), 2294-2303, 1995 | 431 | 1995 |
| Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb Y Yang, G Drossopoulou, PT Chuang, D Duprez, E Marti, D Bumcrot, ... Development 124 (21), 4393-4404, 1997 | 377 | 1997 |
| Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications AE Friedland, R Baral, P Singhal, K Loveluck, S Shen, M Sanchez, ... Genome biology 16, 1-10, 2015 | 340 | 2015 |
| Comparative biological responses to human Sonic, Indian, and Desert hedgehog S Pathi, S Pagan-Westphal, DP Baker, EA Garber, P Rayhorn, D Bumcrot, ... Mechanisms of development 106 (1-2), 107-117, 2001 | 285 | 2001 |
| Delivery and specificity of CRISPR/Cas9 genome editing technologies for human gene therapy JL Gori, PD Hsu, ML Maeder, S Shen, GG Welstead, D Bumcrot Human gene therapy 26 (7), 443-451, 2015 | 249 | 2015 |
| Compositions and methods for inhibiting expression of Eg5 gene D Bumcrot, P Tan, HP Vornlocher, A Geick US Patent 7,718,629, 2010 | 229 | 2010 |
| α-synuclein suppression by targeted small interfering RNA in the primate substantia nigra AL McCormack, SK Mak, JM Henderson, D Bumcrot, MJ Farrer, ... PloS one 5 (8), e12122, 2010 | 227 | 2010 |
| MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer OW Rokhlin, VS Scheinker, AF Taghiyev, D Bumcrot, RA Glover, ... Cancer biology & therapy 7 (8), 1288-1296, 2008 | 214 | 2008 |
| An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia PJ Schmidt, I Toudjarska, AK Sendamarai, T Racie, S Milstein, ... Blood, The Journal of the American Society of Hematology 121 (7), 1200-1208, 2013 | 210 | 2013 |
| Compositions and methods for inhibiting expression of Huntingtin gene DWY Sah, P Hadwiger, I Roehl, B Bramlage, P Tan, HP Vornlocher, ... US Patent 7,320,965, 2008 | 207 | 2008 |
| Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway M John, R Constien, A Akinc, M Goldberg, YA Moon, M Spranger, ... Nature 449 (7163), 745-747, 2007 | 205 | 2007 |
