Lea Starita
Lea Starita
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Network modeling links breast cancer susceptibility and centrosome dysfunction
MA Pujana, JDJ Han, LM Starita, KN Stevens, M Tewari, JS Ahn, ...
Nature genetics 39 (11), 1338-1349, 2007
Accurate classification of BRCA1 variants with saturation genome editing
GM Findlay, RM Daza, B Martin, MD Zhang, AP Leith, M Gasperini, ...
Nature 562 (7726), 217-222, 2018
Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation
DL Swaney, P Beltrao, L Starita, A Guo, J Rush, S Fields, NJ Krogan, ...
Nature methods 10 (7), 676-682, 2013
BRCA1-dependent ubiquitination of γ-tubulin regulates centrosome number
LM Starita, Y Machida, S Sankaran, JE Elias, K Griffin, BP Schlegel, ...
Molecular and cellular biology 24 (19), 8457-8466, 2004
Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework
SE Brnich, AN Abou Tayoun, FJ Couch, GR Cutting, MS Greenblatt, ...
Genome medicine 12, 1-12, 2020
Multiplex assessment of protein variant abundance by massively parallel sequencing
KA Matreyek, LM Starita, JJ Stephany, B Martin, MA Chiasson, VE Gray, ...
Nature genetics 50 (6), 874-882, 2018
Variant interpretation: functional assays to the rescue
LM Starita, N Ahituv, MJ Dunham, JO Kitzman, FP Roth, G Seelig, ...
The American Journal of Human Genetics 101 (3), 315-325, 2017
Massively parallel functional analysis of BRCA1 RING domain variants
LM Starita, DL Young, M Islam, JO Kitzman, J Gullingsrud, RJ Hause, ...
Genetics 200 (2), 413-422, 2015
The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair
LM Starita, JD Parvin
Current opinion in cell biology 15 (3), 345-350, 2003
Cryptic transmission of SARS-CoV-2 in Washington state
T Bedford, AL Greninger, P Roychoudhury, LM Starita, M Famulare, ...
Science 370 (6516), 571-575, 2020
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
X Deng, W Gu, S Federman, L Du Plessis, OG Pybus, NR Faria, C Wang, ...
Science 369 (6503), 582-587, 2020
Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
LM Starita, JN Pruneda, RS Lo, DM Fowler, HJ Kim, JB Hiatt, J Shendure, ...
Proceedings of the National Academy of Sciences 110 (14), E1263-E1272, 2013
Massively parallel single-amino-acid mutagenesis
JO Kitzman, LM Starita, RS Lo, S Fields, J Shendure
Nature methods 12 (3), 203-206, 2015
BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II
LM Starita, AA Horwitz, MC Keogh, C Ishioka, JD Parvin, N Chiba
Journal of Biological Chemistry 280 (26), 24498-24505, 2005
On the design of CRISPR-based single-cell molecular screens
AJ Hill, JL McFaline-Figueroa, LM Starita, MJ Gasperini, KA Matreyek, ...
Nature methods 15 (4), 271-274, 2018
Evidence for limited early spread of COVID-19 within the United States, January–February 2020
MA Jorden, SL Rudman, E Villarino, S Hoferka, MT Patel, K Bemis, ...
Morbidity and Mortality Weekly Report 69 (22), 680-684, 2020
MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect
D Esposito, J Weile, J Shendure, LM Starita, AT Papenfuss, FP Roth, ...
Genome biology 20, 1-11, 2019
The power of multiplexed functional analysis of genetic variants
M Gasperini, L Starita, J Shendure
Nature protocols 11 (10), 1782-1787, 2016
Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination
S Sankaran, LM Starita, AC Groen, MJ Ko, JD Parvin
Molecular and cellular biology 25 (19), 8656-8668, 2005
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells
BP Schlegel, LM Starita, JD Parvin
Oncogene 22 (7), 983-991, 2003
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