Thomas Lavergne
Thomas Lavergne
CNRS-Université Grenoble Alpes
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A semi-synthetic organism with an expanded genetic alphabet
DA Malyshev, K Dhami, T Lavergne, T Chen, N Dai, JM Foster, IR Corręa, ...
Nature 509 (7500), 385-388, 2014
A semisynthetic organism engineered for the stable expansion of the genetic alphabet
Y Zhang, BM Lamb, AW Feldman, AX Zhou, T Lavergne, L Li, ...
Proceedings of the National Academy of Sciences 114 (6), 1317-1322, 2017
Efficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet
DA Malyshev, K Dhami, HT Quach, T Lavergne, P Ordoukhanian, ...
Proceedings of the National Academy of Sciences 109 (30), 12005-12010, 2012
Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications
L Li, M Degardin, T Lavergne, DA Malyshev, K Dhami, P Ordoukhanian, ...
Journal of the American Chemical Society 136 (3), 826-829, 2014
KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry
K Betz, DA Malyshev, T Lavergne, W Welte, K Diederichs, TJ Dwyer, ...
Nature chemical biology 8 (7), 612-614, 2012
Site-specific labeling of DNA and RNA using an efficiently replicated and transcribed class of unnatural base pairs
YJ Seo, DA Malyshev, T Lavergne, P Ordoukhanian, FE Romesberg
Journal of the American Chemical Society 133 (49), 19878-19888, 2011
A Base‐Labile Group for 2′‐OH Protection of Ribonucleosides: A Major Challenge for RNA Synthesis
T Lavergne, JR Bertrand, JJ Vasseur, F Debart
Chemistry-A European Journal 14 (30), 9135-9138, 2008
Structural insights into DNA replication without hydrogen bonds
K Betz, DA Malyshev, T Lavergne, W Welte, K Diederichs, FE Romesberg, ...
Journal of the American Chemical Society 135 (49), 18637-18643, 2013
Efficient solid-phase chemical synthesis of 5′-triphosphates of DNA, RNA, and their analogues
I Zlatev, T Lavergne, F Debart, JJ Vasseur, M Manoharan, F Morvan
Organic letters 12 (10), 2190-2193, 2010
Chemical RNA synthesis method
F Debart, J Vasseur, T Lavergne
US Patent 8,536,318, 2013
Major groove substituents and polymerase recognition of a class of predominantly hydrophobic unnatural base pairs
T Lavergne, MDA Malyshev, FE Romesberg
Chemistry (Weinheim an der Bergstrasse, Germany) 18 (4), 1231, 2012
Expanding the scope of replicable unnatural DNA: stepwise optimization of a predominantly hydrophobic base pair
T Lavergne, M Degardin, DA Malyshev, HT Quach, K Dhami, ...
Journal of the American Chemical Society 135 (14), 5408-5419, 2013
FRET characterization of complex conformational changes in a large 16S ribosomal RNA fragment site-specifically labeled using unnatural base pairs
T Lavergne, R Lamichhane, DA Malyshev, Z Li, L Li, E Sperling, ...
ACS chemical biology 11 (5), 1347-1353, 2016
New Ruthenium‐Based Probes for Selective G‐Quadruplex Targeting
G Piraux, L Bar, M Abraham, T Lavergne, H Jamet, J Dejeu, L Marcélis, ...
Chemistry–A European Journal 23 (49), 11872-11880, 2017
Template‐Mediated Stabilization of a DNA G‐Quadruplex formed in the HIV‐1 Promoter and Comparative Binding Studies
L Bonnat, L Bar, B Génnaro, H Bonnet, O Jarjayes, F Thomas, J Dejeu, ...
Chemistry-A European Journal 23 (23), 5602-5613, 2017
Synthesis and Preliminary Evaluation of pro-RNA 2′-O-Masked with Biolabile Pivaloyloxymethyl Groups in an RNA Interference Assay
T Lavergne, C Baraguey, C Dupouy, N Parey, W Wuensche, G Sczakiel, ...
The Journal of organic chemistry 76 (14), 5719-5731, 2011
Assessment of new 2′-O-acetalester protecting groups for regular RNA synthesis and original 2′-modified proRNA
AR Martin, T Lavergne, JJ Vasseur, F Debart
Bioorganic & medicinal chemistry letters 19 (15), 4046-4049, 2009
Efficient Inhibition of Telomerase by Nickel–Salophen Complexes
L Lecarme, E Prado, A De Rache, ML Nicolau‐Travers, G Gellon, J Dejeu, ...
ChemMedChem 11 (11), 1133-1136, 2016
Construction of anti-parallel G-quadruplexes through sequential templated click
R Bonnet, T Lavergne, B Gennaro, N Spinelli, E Defrancq
Chemical Communications 51 (23), 4850-4853, 2015
Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands
L Bonnat, M Dautriche, T Saidi, J Revol-Cavalier, J Dejeu, E Defrancq, ...
Organic & biomolecular chemistry 17 (38), 8726-8736, 2019
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