| Enhancer evolution across 20 mammalian species D Villar, C Berthelot, S Aldridge, TF Rayner, M Lukk, M Pignatelli, TJ Park, ... Cell 160 (3), 554-566, 2015 | 787 | 2015 |
| Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1 N Pescador, D Villar, D Cifuentes, M Garcia-Rocha, A Ortiz-Barahona, ... PloS one 5 (3), e9644, 2010 | 313 | 2010 |
| Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene N Pescador, Y Cuevas, S Naranjo, M Alcaide, D Villar, MO Landázuri, ... Biochemical Journal 390 (1), 189-197, 2005 | 289 | 2005 |
| Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding … A Ortiz-Barahona, D Villar, N Pescador, J Amigo, L del Peso Nucleic acids research 38 (7), 2332-2345, 2010 | 247 | 2010 |
| Evolution of transcription factor binding in metazoans—mechanisms and functional implications D Villar, P Flicek, DT Odom Nature Reviews Genetics 15 (4), 221-233, 2014 | 246 | 2014 |
| Universal DNA methylation age across mammalian tissues AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li, R Lowe, Q Yan, ... Nature aging 3 (9), 1144-1166, 2023 | 178 | 2023 |
| Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression C Berthelot, D Villar, JE Horvath, DT Odom, P Flicek Nature ecology & evolution 2 (1), 152-163, 2018 | 152 | 2018 |
| Codon-driven translational efficiency is stable across diverse mammalian cell states KLM Rudolph, BM Schmitt, D Villar, RJ White, JC Marioni, C Kutter, ... PLoS genetics 12 (5), e1006024, 2016 | 96 | 2016 |
| Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease JR Naranjo, H Zhang, D Villar, P González, XM Dopazo, J Morón-Oset, ... The Journal of clinical investigation 126 (2), 627-638, 2016 | 76 | 2016 |
| Interaction between PARP-1 and HIF-2α in the hypoxic response A Gonzalez-Flores, R Aguilar-Quesada, E Siles, S Pozo, ... Oncogene 33 (7), 891-898, 2014 | 76 | 2014 |
| DNA methylation networks underlying mammalian traits A Haghani, CZ Li, TR Robeck, J Zhang, AT Lu, J Ablaeva, ... Science 381 (6658), eabq5693, 2023 | 74 | 2023 |
| LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions M Roller, E Stamper, D Villar, O Izuogu, F Martin, AM Redmond, ... Genome biology 22, 1-43, 2021 | 58 | 2021 |
| Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains D Villar, A Vara-Vega, MO Landázuri, L Del Peso Biochemical Journal 408 (2), 231-240, 2007 | 54 | 2007 |
| Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions D Villar, A Ortiz-Barahona, L Gómez-Maldonado, N Pescador, ... PLoS One 7 (9), e45708, 2012 | 49 | 2012 |
| Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data T Rensch, D Villar, J Horvath, DT Odom, P Flicek Genome biology 17, 1-14, 2016 | 38 | 2016 |
| Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate AJ Jasinska, I Zelaya, SK Service, CB Peterson, RM Cantor, OW Choi, ... Nature genetics 49 (12), 1714-1721, 2017 | 33 | 2017 |
| Building the DREAM interactome M Rivas, D Villar, P González, XM Dopazo, B Mellstrom, JR Naranjo Science China Life Sciences 54, 786-792, 2011 | 24 | 2011 |
| The contribution of non-coding regulatory elements to cardiovascular disease D Villar, S Frost, P Deloukas, A Tinker Open Biology 10 (7), 200088, 2020 | 23 | 2020 |
| Epigenetic predictors of maximum lifespan and other life history traits in mammals CZ Li, A Haghani, TR Robeck, D Villar, AT Lu, J Zhang, CG Faulkes, H Vu, ... BioRxiv, 2021.05. 16.444078, 2021 | 19 | 2021 |
| A role for insulator elements in the regulation of gene expression response to hypoxia M Tiana, D Villar, E Perez-Guijarro, L Gomez-Maldonado, E Molto, ... Nucleic acids research 40 (5), 1916-1927, 2012 | 18 | 2012 |
