CRISPR–Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters MM Zhang, FT Wong, Y Wang, S Luo, YH Lim, E Heng, WL Yeo, RE Cobb, ... Nature chemical biology 13 (6), 607-609, 2017 | 303 | 2017 |
Directed evolution of enzymes for industrial biocatalysis JL Porter, RA Rusli, DL Ollis ChemBioChem 17 (3), 197-203, 2016 | 278 | 2016 |
Recent advances in the bioremediation of persistent organic pollutants via biomolecular engineering EL Ang, H Zhao, JP Obbard Enzyme and microbial technology 37 (5), 487-496, 2005 | 247 | 2005 |
Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates H Sun, H Zhang, EL Ang, H Zhao Bioorganic & medicinal chemistry 26 (7), 1275-1284, 2018 | 234 | 2018 |
A highly efficient single-step, markerless strategy for multi-copy chromosomal integration of large biochemical pathways in Saccharomyces cerevisiae S Shi, Y Liang, MM Zhang, EL Ang, H Zhao Metabolic engineering 33, 19-27, 2016 | 228 | 2016 |
Engineering microbial hosts for production of bacterial natural products MM Zhang, Y Wang, EL Ang, H Zhao Natural product reports 33 (8), 963-987, 2016 | 155 | 2016 |
Metabolic engineering of a synergistic pathway for n-butanol production in Saccharomyces cerevisiae S Shi, T Si, Z Liu, H Zhang, EL Ang, H Zhao Scientific reports 6 (1), 25675, 2016 | 120 | 2016 |
Recent advances in combinatorial biosynthesis for drug discovery H Sun, Z Liu, H Zhao, EL Ang Drug Design, Development and Therapy, 823-833, 2015 | 104 | 2015 |
Recent developments in the application of P450 based biocatalysts Y Wei, EL Ang, H Zhao Current Opinion in Chemical Biology 43, 1-7, 2018 | 100 | 2018 |
Using natural products for drug discovery: the impact of the genomics era MM Zhang, Y Qiao, EL Ang, H Zhao Expert opinion on drug discovery 12 (5), 475-487, 2017 | 84 | 2017 |
A widespread pathway for substitution of adenine by diaminopurine in phage genomes Y Zhou, X Xu, Y Wei, Y Cheng, Y Guo, I Khudyakov, F Liu, P He, Z Song, ... Science 372 (6541), 512-516, 2021 | 78 | 2021 |
In vivo biosensors: mechanisms, development, and applications S Shi, EL Ang, H Zhao Journal of Industrial Microbiology and Biotechnology 45 (7), 491-516, 2018 | 75 | 2018 |
Engineered pentafunctional minicellulosome for simultaneous saccharification and ethanol fermentation in Saccharomyces cerevisiae Y Liang, T Si, EL Ang, H Zhao Applied and environmental microbiology 80 (21), 6677-6684, 2014 | 68 | 2014 |
Production of adipic acid from sugar beet residue by combined biological and chemical catalysis H Zhang, X Li, X Su, EL Ang, Y Zhang, H Zhao ChemCatChem 8 (8), 1500-1506, 2016 | 59 | 2016 |
Radical-mediated CS bond cleavage in C2 sulfonate degradation by anaerobic bacteria M Xing, Y Wei, Y Zhou, J Zhang, L Lin, Y Hu, G Hua, A N. Nanjaraj Urs, ... Nature communications 10 (1), 1609, 2019 | 58 | 2019 |
Directed evolution of a fluorinase for improved fluorination efficiency with a non‐native substrate H Sun, WL Yeo, YH Lim, X Chew, DJ Smith, B Xue, KP Chan, ... Angewandte Chemie 128 (46), 14489-14492, 2016 | 58 | 2016 |
Discovery and engineering of a 1-butanol biosensor in Saccharomyces cerevisiae S Shi, YW Choi, H Zhao, MH Tan, EL Ang Bioresource technology 245, 1343-1351, 2017 | 57 | 2017 |
Directed evolution of aniline dioxygenase for enhanced bioremediation of aromatic amines EL Ang, JP Obbard, H Zhao Applied microbiology and biotechnology 81, 1063-1070, 2009 | 55 | 2009 |
Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole D Liu, Y Wei, X Liu, Y Zhou, L Jiang, J Yin, F Wang, Y Hu, ... Nature communications 9 (1), 4224, 2018 | 54 | 2018 |
Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR‐Cas9 Activation YH Lim, FT Wong, WL Yeo, KC Ching, YW Lim, E Heng, S Chen, DJ Tsai, ... ChemBioChem 19 (16), 1716-1719, 2018 | 53 | 2018 |