Christopher S Theile
Christopher S Theile
Alnylam Pharmaceuticals
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Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions
CP Guimaraes, MD Witte, CS Theile, G Bozkurt, L Kundrat, AEM Blom, ...
Nature protocols 8 (9), 1787-1799, 2013
Site-specific N-terminal labeling of proteins using sortase-mediated reactions
CS Theile, MD Witte, AEM Blom, L Kundrat, HL Ploegh, CP Guimaraes
Nature protocols 8 (9), 1800-1807, 2013
Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes
J Shi, L Kundrat, N Pishesha, A Bilate, C Theile, T Maruyama, SK Dougan, ...
Proceedings of the National Academy of Sciences 111 (28), 10131-10136, 2014
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
CR Brown, S Gupta, J Qin, T Racie, G He, S Lentini, R Malone, M Yu, ...
Nucleic acids research 48 (21), 11827-11844, 2020
5′‐(E)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates
R Parmar, JLS Willoughby, J Liu, DJ Foster, B Brigham, CS Theile, ...
ChemBioChem 17 (11), 985-989, 2016
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
KM Brown, JK Nair, MM Janas, YI Anglero-Rodriguez, LTH Dang, H Peng, ...
Nature biotechnology 40 (10), 1500-1508, 2022
Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry
MD Witte, CS Theile, T Wu, CP Guimaraes, AEM Blom, HL Ploegh
Nature protocols 8 (9), 1808-1819, 2013
siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2
E Elkayam, R Parmar, CR Brown, JL Willoughby, CS Theile, ...
Nucleic acids research 45 (6), 3528-3536, 2017
Site-specific protein modification using immobilized sortase in batch and continuous-flow systems
MD Witte, T Wu, CP Guimaraes, CS Theile, AEM Blom, JR Ingram, Z Li, ...
Nature Protocols 10 (3), 508-516, 2015
Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells
AM Avalos, AM Bilate, MD Witte, AK Tai, J He, MP Frushicheva, PD Thill, ...
Journal of Experimental Medicine 211 (2), 365-379, 2014
Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors
I Wuethrich, JGC Peeters, AEM Blom, CS Theile, Z Li, E Spooner, ...
PLoS One 9 (10), e109883, 2014
Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling
AS Jahan, M Lestra, LK Swee, Y Fan, MM Lamers, FG Tafesse, CS Theile, ...
Proceedings of the National Academy of Sciences 113 (6), E705-E714, 2016
Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates
RG Parmar, CR Brown, S Matsuda, JLS Willoughby, CS Theile, ...
Journal of medicinal chemistry 61 (3), 734-744, 2018
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence …
R McDougall, D Ramsden, S Agarwal, S Agarwal, K Aluri, M Arciprete, ...
Drug Metabolism and Disposition 50 (6), 781-797, 2022
A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short‐term plasticity and vesicle number
BJ Walters, JJ Hallengren, CS Theile, HL Ploegh, SM Wilson, LE Dobrunz
The Journal of physiology 592 (4), 571-586, 2014
Centyrin ligands for extrahepatic delivery of siRNA
D Klein, S Goldberg, CS Theile, R Dambra, K Haskell, E Kuhar, T Lin, ...
Molecular Therapy 29 (6), 2053-2066, 2021
Generation and validation of structurally defined antibody–siRNA conjugates
AR Nanna, AV Kel’in, C Theile, JM Pierson, ZX Voo, A Garg, JK Nair, ...
Nucleic Acids Research 48 (10), 5281-5293, 2020
Fluorophore‐Conjugated Holliday Junctions for Generating Super‐Bright Antibodies and Antibody Fragments
Z Li, CS Theile, GY Chen, AM Bilate, JN Duarte, AM Avalos, T Fang, ...
Angewandte Chemie International Edition 54 (40), 11706-11710, 2015
Graphene Oxide Nanosheets Modified with Single‐Domain Antibodies for Rapid and Efficient Capture of Cells
GY Chen, Z Li, CS Theile, NM Bardhan, PV Kumar, JN Duarte, ...
Chemistry–A European Journal 21 (48), 17178-17183, 2015
The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man
S Chong, S Agarwal, S Agarwal, KC Aluri, M Arciprete, C Brown, ...
Drug Metabolism and Disposition, 2021
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