John M. Pascal
John M. Pascal
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Structural basis for DNA damage–dependent poly (ADP-ribosyl) ation by human PARP-1
MF Langelier, JL Planck, S Roy, JM Pascal
Science 336 (6082), 728-732, 2012
Dual roles of PARP-1 promote cancer growth and progression
MJ Schiewer, JF Goodwin, S Han, JC Brenner, MA Augello, JL Dean, ...
Cancer discovery 2 (12), 1134-1149, 2012
Human DNA ligase I completely encircles and partially unwinds nicked DNA
JM Pascal, PJ O'Brien, AE Tomkinson, T Ellenberger
Nature 432 (7016), 473-478, 2004
DNA ligases: structure, reaction mechanism, and function
AE Tomkinson, S Vijayakumar, JM Pascal, T Ellenberger
Chemical reviews 106 (2), 687-699, 2006
Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis …
JA Platts-Mills, J Liu, ET Rogawski, F Kabir, P Lertsethtakarn, M Siguas, ...
The Lancet Global Health 6 (12), e1309-e1318, 2018
The comings and goings of PARP-1 in response to DNA damage
JM Pascal
DNA repair 71, 177-182, 2018
A third zinc-binding domain of human poly (ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation
MF Langelier, KM Servent, EE Rogers, JM Pascal
Journal of biological chemistry 283 (7), 4105-4114, 2008
PARP-1 activation requires local unfolding of an autoinhibitory domain
JM Dawicki-McKenna, MF Langelier, JE DeNizio, AA Riccio, CD Cao, ...
Molecular cell 60 (5), 755-768, 2015
Structural basis of detection and signaling of DNA single-strand breaks by human PARP-1
S Eustermann, WF Wu, MF Langelier, JC Yang, LE Easton, AA Riccio, ...
Molecular cell 60 (5), 742-754, 2015
Use of quantitative molecular diagnostic methods to investigate the effect of enteropathogen infections on linear growth in children in low-resource settings: longitudinal …
ET Rogawski, J Liu, JA Platts-Mills, F Kabir, P Lertsethtakarn, M Siguas, ...
The Lancet Global Health 6 (12), e1319-e1328, 2018
Crystal structures of poly (ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity
MF Langelier, JL Planck, S Roy, JM Pascal
Journal of biological chemistry 286 (12), 10690-10701, 2011
PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
MF Langelier, AA Riccio, JM Pascal
Nucleic acids research 42 (12), 7762-7775, 2014
Structural basis for allosteric PARP-1 retention on DNA breaks
L Zandarashvili, MF Langelier, UK Velagapudi, MA Hancock, JD Steffen, ...
Science 368 (6486), eaax6367, 2020
PARP-1 mechanism for coupling DNA damage detection to poly (ADP-ribose) synthesis
MF Langelier, JM Pascal
Current opinion in structural biology 23 (1), 134-143, 2013
Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED birth cohort study
MN Kosek, T Ahmed, Z Bhutta, L Caulfield, R Guerrant, E Houpt, G Kang, ...
EBioMedicine 18, 109-117, 2017
The Zn3 domain of human poly (ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly (ADP-ribose) synthesis activity and chromatin compaction
MF Langelier, DD Ruhl, JL Planck, WL Kraus, JM Pascal
Journal of biological chemistry 285 (24), 18877-18887, 2010
NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains
MF Langelier, L Zandarashvili, PM Aguiar, BE Black, JM Pascal
Nature communications 9 (1), 844, 2018
ADP‐ribosyltransferases, an update on function and nomenclature
B Lüscher, I Ahel, M Altmeyer, A Ashworth, P Bai, P Chang, M Cohen, ...
The FEBS journal 289 (23), 7399-7410, 2022
Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study
C Amour, J Gratz, E Mduma, E Svensen, ET Rogawski, M McGrath, ...
Clinical Infectious Diseases 63 (9), 1171-1179, 2016
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA
JM Pascal, OV Tsodikov, GL Hura, W Song, EA Cotner, S Classen, ...
Molecular cell 24 (2), 279-291, 2006
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