Adenovirus-associated virus vector–mediated gene transfer in hemophilia B AC Nathwani, EGD Tuddenham, S Rangarajan, C Rosales, J McIntosh, ... New England Journal of Medicine 365 (25), 2357-2365, 2011 | 2190 | 2011 |
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2 S Rost, A Fregin, V Ivaskevicius, E Conzelmann, K Hörtnagel, HJ Pelz, ... Nature 427 (6974), 537-541, 2004 | 1503 | 2004 |
Long-term safety and efficacy of factor IX gene therapy in hemophilia B AC Nathwani, UM Reiss, EGD Tuddenham, C Rosales, P Chowdary, ... New England Journal of Medicine 371 (21), 1994-2004, 2014 | 1409 | 2014 |
The hemophilias—from royal genes to gene therapy PM Mannucci, EGD Tuddenham New England Journal of Medicine 344 (23), 1773-1779, 2001 | 1384 | 2001 |
Structure of human factor VIII GA Vehar, B Keyt, D Eaton, H Rodriguez, DP O'Brien, F Rotblat, ... Nature 312 (5992), 337-342, 1984 | 1223 | 1984 |
Expression of active human factor VIII from recombinant DNA clones WI Wood, DJ Capon, CC Simonsen, DL Eaton, J Gitschier, B Keyt, ... Nature 312 (5992), 330-337, 1984 | 954 | 1984 |
Postgraduate haematology AV Hoffbrand, DR Higgs, DM Keeling, AB Mehta John Wiley & Sons, 2016 | 714 | 2016 |
Biopsy of human preimplantation embryos and sexing by DNA amplification AH Handyside, RJA Penketh, RML Winston, JK Pattinson, JDA Delhanty, ... The Lancet 333 (8634), 347-349, 1989 | 689 | 1989 |
Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and … AC Nathwani, JT Gray, CYC Ng, J Zhou, Y Spence, SN Waddington, ... Blood 107 (7), 2653-2661, 2006 | 503 | 2006 |
Haemophilia A: mutation type determines risk of inhibitor formation R Schwaab, HH Brackmann, C Meyer, J Seehafer, M Kirchgesser, ... Thrombosis and haemostasis 74 (12), 1402-1406, 1995 | 437 | 1995 |
Distribution of factor VIII mRNA and antigen in human liver and other tissues KL Wion, D Kelly, JA Summerfield, EGD Tuddenham, RM Lawn Nature 317 (6039), 726-729, 1985 | 404 | 1985 |
Genetic mapping and diagnosis of haemophilia A achieved through a BclI polymorphism in the factor VIII gene J Gitschier, D Drayna, EGD Tuddenham, RL White, RM Lawn Nature 314 (6013), 738-740, 1985 | 327 | 1985 |
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex B Zhang, MA Cunningham, WC Nichols, JA Bernat, U Seligsohn, SW Pipe, ... Nature genetics 34 (2), 220-225, 2003 | 326 | 2003 |
Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman … AC Nathwani, JT Gray, J McIntosh, CYC Ng, J Zhou, Y Spence, ... Blood 109 (4), 1414-1421, 2007 | 323 | 2007 |
Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA NBY Tsui, RA Kadir, KCA Chan, C Chi, G Mellars, EG Tuddenham, ... Blood, The Journal of the American Society of Hematology 117 (13), 3684-3691, 2011 | 321 | 2011 |
Tissue factor: an enzyme cofactor and a true receptor JH Morrissey Thrombosis and haemostasis 86 (07), 66-74, 2001 | 315 | 2001 |
Crystal structure of the extracellular region of human tissue factor K Harlos, DMA Martin, DP O'brien, EY Jones, DI Stuart, I Polikarpov, ... Nature 370 (6491), 662-666, 1994 | 309 | 1994 |
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant J McIntosh, PJ Lenting, C Rosales, D Lee, S Rabbanian, D Raj, N Patel, ... Blood, The Journal of the American Society of Hematology 121 (17), 3335-3344, 2013 | 308 | 2013 |
High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction J O’donnell, EGD Tuddenham, R Manning, G Kemball-Cook, D Johnson, ... Thrombosis and haemostasis 77 (05), 0825-0828, 1997 | 305 | 1997 |
The factor VIII structure and mutation resource site: HAMSTeRS version 4 G Kemball-Cook, EGD Tuddenham, AI Wacey Nucleic Acids Research 26 (1), 216-219, 1998 | 284 | 1998 |