Matthias Gaestel
Matthias Gaestel
Professor of Biochemistry at MHH
Verified email at - Homepage
Cited by
Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
Small heat shock proteins are molecular chaperones.
U Jakob, M Gaestel, K Engel, J Buchner
Journal of Biological Chemistry 268 (3), 1517-1520, 1993
MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
A Kotlyarov, A Neininger, C Schubert, R Eckert, C Birchmeier, HD Volk, ...
Nature cell biology 1 (2), 94-97, 1999
Binding of non‐native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation
M Ehrnsperger, S Gräber, M Gaestel, J Buchner
The EMBO journal, 1997
The p38 MAP kinase pathway signals for cytokine‐induced mRNA stabilization via MAP kinase‐activated protein kinase 2 and an AU‐rich region‐targeted mechanism
R Winzen, M Kracht, B Ritter, A Wilhelm, CYA Chen, AB Shyu, M Müller, ...
The EMBO journal, 1999
Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor α by phosphorylation
T Rogalla, M Ehrnsperger, X Preville, A Kotlyarov, G Lutsch, C Ducasse, ...
Journal of Biological Chemistry 274 (27), 18947-18956, 1999
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
D Stokoe, K Engel, DG Campbell, P Cohen, M Gaestel
FEBS letters 313 (3), 307-313, 1992
TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord
A Kroner, AD Greenhalgh, JG Zarruk, RP Dos Santos, M Gaestel, S David
Neuron 83 (5), 1098-1116, 2014
MAPKAP kinases—MKs—two's company, three's a crowd
M Gaestel
Nature reviews Molecular cell biology 7 (2), 120-130, 2006
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
A Neininger, D Kontoyiannis, A Kotlyarov, R Winzen, R Eckert, HD Volk, ...
Journal of Biological Chemistry 277 (5), 3065-3068, 2002
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression …
E Hitti, T Iakovleva, M Brook, S Deppenmeier, AD Gruber, D Radzioch, ...
Molecular and cellular biology, 2006
Targeting innate immunity protein kinase signalling in inflammation
M Gaestel, A Kotlyarov, M Kracht
Nature Reviews Drug Discovery 8 (6), 480-499, 2009
Leptomycin B‐sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation
K Engel, A Kotlyarov, M Gaestel
The EMBO journal, 1998
Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway
P Kovarik, D Stoiber, PA Eyers, R Menghini, A Neininger, M Gaestel, ...
Proceedings of the National Academy of Sciences 96 (24), 13956-13961, 1999
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor–induced Crohn's-like inflammatory bowel disease
D Kontoyiannis, G Boulougouris, M Manoloukos, M Armaka, M Apostolaki, ...
The Journal of experimental medicine 196 (12), 1563-1574, 2002
Interleukin‐10 targets p38 MAPK to modulate ARE‐dependent TNF mRNA translation and limit intestinal pathology
D Kontoyiannis, A Kotlyarov, E Carballo, L Alexopoulou, PJ Blackshear, ...
The EMBO journal, 2001
Distinct cellular functions of MK2
A Kotlyarov, Y Yannoni, S Fritz, K Laaß, JB Telliez, D Pitman, LL Lin, ...
Molecular and cellular biology 22 (13), 4827-4835, 2002
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP‐K2 and its interaction with cytokine mRNAs
S Rousseau, N Morrice, M Peggie, DG Campbell, M Gaestel, P Cohen
The EMBO journal, 2002
p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level
A Pietersma, BC Tilly, M Gaestel, N de Jong, JC Lee, JF Koster, W Sluiter
Biochemical and biophysical research communications 230 (1), 44-48, 1997
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK
N Ronkina, A Kotlyarov, O Dittrich-Breiholz, M Kracht, E Hitti, K Milarski, ...
Molecular and cellular biology, 2007
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