Stefan Knapp

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Panagis FilippakopoulosAssociate Professor, Oxford UniversityVerified email at sgc.ox.ac.uk
Oleg FedorovUniversity of OxfordVerified email at cmd.ox.ac.uk
Apirat ChaikuadVerified email at pharmchem.uni-frankfurt.de
Paul E BrennanUniversity of OxfordVerified email at cmd.ox.ac.uk
Frank von DelftPrincipal Investigator: Protein Crystallography, SGC, Oxford UniversityVerified email at sgc.ox.ac.uk
Brian MarsdenCentre for Medicines Discovery & Wellcome Centre for Human GeneticsVerified email at cmd.ox.ac.uk
Wen Hwa LeeAction Against AMD, SGC and University of OxfordVerified email at actionagainstamd.org
Cheryl ArrowsmithSenior Scientist, Princess Margaret Cancer Centre & Professor of Medical Biophysics, University of TorontoVerified email at uhnres.utoronto.ca
Benjamin E. TurkYale UniversityVerified email at yale.edu
Nathanael GrayProfessor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at dfci.harvard.edu
Jeyanthy EswaranSaint Jude's Children's Research HospitalVerified email at stjude.org
Opher GileadiSGC, Karolinska InstituteVerified email at ki.se
Juerg SchwallerProfessor Universität BaselVerified email at unibas.ch
Martin SchröderNovartis Institute for Biomedical ResearchVerified email at novartis.com
Ashley PikeCentre for Medicines Discovery - University of OxfordVerified email at cmd.ox.ac.uk
Kilian V. M. HuberPrincipal Investigator, University of OxfordVerified email at cmd.ox.ac.uk
Stuart J ConwayJung Chair in Medicinal Chemistry, University of California, Los AngelesVerified email at chem.ucla.edu
James BradnerNovartis Institutes for BioMedical ResearchVerified email at novartis.com
Laurent MeijerVerified email at manros-therapeutics.com
David Harold DrewryProfessor University of North Carolina Chapel HillVerified email at unc.edu

Stefan Knapp

University of Frankfurt

Verified email at pharmchem.uni-frankfurt.de

bromodomains kinases structural biology drug design


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Selective inhibition of BET bromodomains P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith, O Fedorov, ... Nature 468 (7327), 1067-1073, 2010	3964	2010
Histone recognition and large-scale structural analysis of the human bromodomain family P Filippakopoulos, S Picaud, M Mangos, T Keates, JP Lambert, ... Cell 149 (1), 214-231, 2012	1596	2012
Targeting bromodomains: epigenetic readers of lysine acetylation P Filippakopoulos, S Knapp Nature reviews Drug discovery 13 (5), 337-356, 2014	1236	2014
Protein production and purification Architecture et Fonction des Macromolécules Biologiques Vincentelli Renaud 4 ... Nature methods 5 (2), 135-146, 2008	982	2008
The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015	785	2015
Critical residues for structure and catalysis in short-chain dehydrogenases/reductases C Filling, KD Berndt, J Benach, S Knapp, T Prozorovski, E Nordling, ... Journal of Biological Chemistry 277 (28), 25677-25684, 2002	655	2002
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs KL Kavanagh, K Guo, JE Dunford, X Wu, S Knapp, FH Ebetino, ... Proceedings of the National Academy of Sciences 103 (20), 7829-7834, 2006	625	2006
Bromodomains as therapeutic targets S Muller, P Filippakopoulos, S Knapp Expert reviews in molecular medicine 13, e29, 2011	528	2011
Large-scale structural analysis of the classical human protein tyrosine phosphatome AJ Barr, E Ugochukwu, WH Lee, ONF King, P Filippakopoulos, I Alfano, ... Cell 136 (2), 352-363, 2009	514	2009
Linear motif atlas for phosphorylation-dependent signaling ML Miller, LJ Jensen, F Diella, C Jørgensen, M Tinti, L Li, M Hsiung, ... Science signaling 1 (35), ra2-ra2, 2008	512	2008
Small-molecule inhibition of BRDT for male contraception MM Matzuk, MR McKeown, P Filippakopoulos, Q Li, L Ma, JE Agno, ... Cell 150 (4), 673-684, 2012	475	2012
Copper is required for oncogenic BRAF signalling and tumorigenesis DC Brady, MS Crowe, ML Turski, GA Hobbs, X Yao, A Chaikuad, S Knapp, ... Nature 509 (7501), 492-496, 2014	459	2014
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ... Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013	440	2013
The bromodomain interaction module P Filippakopoulos, S Knapp FEBS letters 586 (17), 2692-2704, 2012	432	2012
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy KVM Huber, E Salah, B Radic, M Gridling, JM Elkins, A Stukalov, ... Nature 508 (7495), 222-227, 2014	412	2014
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers L Brault, C Gasser, F Bracher, K Huber, S Knapp, J Schwaller haematologica 95 (6), 1004, 2010	405	2010
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases O Fedorov, B Marsden, V Pogacic, P Rellos, S Müller, AN Bullock, ... Proceedings of the National Academy of Sciences 104 (51), 20523-20528, 2007	403	2007
Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’binding mechanism for the spindle checkpoint L Sironi, M Mapelli, S Knapp, A De Antoni, KT Jeang, A Musacchio The EMBO journal 21 (10), 2496-2506, 2002	385	2002
Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery? Z Zhao, H Wu, L Wang, Y Liu, S Knapp, Q Liu, NS Gray ACS chemical biology 9 (6), 1230-1241, 2014	381	2014
The (un) targeted cancer kinome O Fedorov, S Müller, S Knapp Nature chemical biology 6 (3), 166-169, 2010	356	2010

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