James Shorter
James Shorter
Professor of Biochemistry and Biophysics, University of Pennsylvania
Verified email at - Homepage
Cited by
Cited by
Protein phase separation: a new phase in cell biology
S Boeynaems, S Alberti, NL Fawzi, T Mittag, M Polymenidou, F Rousseau, ...
Trends in cell biology 28 (6), 420-435, 2018
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
HJ Kim, NC Kim, YD Wang, EA Scarborough, J Moore, Z Diaz, ...
Nature 495 (7442), 467-473, 2013
Stress granules as crucibles of ALS pathogenesis
YR Li, OD King, J Shorter, AD Gitler
Journal of cell biology 201 (3), 361-372, 2013
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity
BS Johnson, D Snead, JJ Lee, JM McCaffery, J Shorter, AD Gitler
Journal of Biological Chemistry 284 (30), 20329-20339, 2009
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
OD King, AD Gitler, J Shorter
Brain research 1462, 61-80, 2012
Neurodegenerative disease: models, mechanisms, and a new hope
AD Gitler, P Dhillon, J Shorter
Disease models & mechanisms 10 (5), 499-502, 2017
The molecular language of membraneless organelles
E Gomes, J Shorter
Journal of Biological Chemistry 294 (18), 7115-7127, 2019
The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis
AD Gitler, BJ Bevis, J Shorter, KE Strathearn, S Hamamichi, LJ Su, ...
Proceedings of the National Academy of Sciences 105 (1), 145-150, 2008
Prions as adaptive conduits of memory and inheritance
J Shorter, S Lindquist
Nature Reviews Genetics 6 (6), 435-450, 2005
Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers
J Shorter, S Lindquist
Science 304 (5678), 1793-1797, 2004
A complex of mammalian ufd1 and npl4 links the AAA‐ATPase, p97, to ubiquitin and nuclear transport pathways
HH Meyer, JG Shorter, J Seemann, D Pappin, G Warren
The EMBO journal, 2000
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS
Z Sun, Z Diaz, X Fang, MP Hart, A Chesi, J Shorter, AD Gitler
PLoS biology 9 (4), e1000614, 2011
A yeast functional screen predicts new candidate ALS disease genes
J Couthouis, MP Hart, J Shorter, M DeJesus-Hernandez, R Erion, ...
Proceedings of the National Academy of Sciences 108 (52), 20881-20890, 2011
Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains
L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ...
Cell 173 (3), 677-692. e20, 2018
RNA-binding proteins with prion-like domains in health and disease
AF Harrison, J Shorter
Biochemical Journal 474 (8), 1417-1438, 2017
Golgi architecture and inheritance
J Shorter, G Warren
Annual review of cell and developmental biology 18 (1), 379-420, 2002
RNA binding antagonizes neurotoxic phase transitions of TDP-43
JR Mann, AM Gleixner, JC Mauna, E Gomes, MR DeChellis-Marks, ...
Neuron 102 (2), 321-338. e8, 2019
GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system
J Shorter, R Watson, ME Giannakou, M Clarke, G Warren, FA Barr
The EMBO journal 18 (18), 4949-4960, 1999
Cytoplasmic TDP-43 de-mixing independent of stress granules drives inhibition of nuclear import, loss of nuclear TDP-43, and cell death
F Gasset-Rosa, S Lu, H Yu, C Chen, Z Melamed, L Guo, J Shorter, ...
Neuron 102 (2), 339-357. e7, 2019
The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system
J Shorter
PloS one 6 (10), e26319, 2011
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