Ivan Zlatev
Ivan Zlatev
Alnylam Pharmaceuticals
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Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
N Iwamoto, DCD Butler, N Svrzikapa, S Mohapatra, I Zlatev, DWY Sah, ...
Nature biotechnology 35 (9), 845-851, 2017
Influenza A virus-generated small RNAs regulate the switch from transcription to replication
JT Perez, A Varble, R Sachidanandam, I Zlatev, M Manoharan, ...
Proceedings of the National Academy of Sciences 107 (25), 11525-11530, 2010
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
MM Janas, MK Schlegel, CE Harbison, VO Yilmaz, Y Jiang, R Parmar, ...
Nature communications 9 (1), 723, 2018
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
CR Brown, S Gupta, J Qin, T Racie, G He, S Lentini, R Malone, M Yu, ...
Nucleic acids research 48 (21), 11827-11844, 2020
Crystal structure of Middle East respiratory syndrome coronavirus helicase
W Hao, JA Wojdyla, R Zhao, R Han, R Das, I Zlatev, M Manoharan, ...
PLoS pathogens 13 (6), e1006474, 2017
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
KM Brown, JK Nair, MM Janas, YI Anglero-Rodriguez, LTH Dang, H Peng, ...
Nature biotechnology 40 (10), 1500-1508, 2022
Chiral control
D Butler, N Iwamoto, N Svrzikapa, GL Verdine, I ZLATEV
US Patent 9,982,257, 2018
Strong and sustained antihypertensive effect of small interfering RNA targeting liver angiotensinogen
E Uijl, KM Mirabito Colafella, Y Sun, L Ren, R van Veghel, IM Garrelds, ...
Hypertension 73 (6), 1249-1257, 2019
A small-RNA enhancer of viral polymerase activity
JT Perez, I Zlatev, S Aggarwal, S Subramanian, R Sachidanandam, B Kim, ...
Journal of virology 86 (24), 13475-13485, 2012
Reversal of siRNA-mediated gene silencing in vivo
I Zlatev, A Castoreno, CR Brown, J Qin, S Waldron, MK Schlegel, ...
Nature biotechnology 36 (6), 509-511, 2018
Chirality dependent potency enhancement and structural impact of glycol nucleic acid modification on siRNA
MK Schlegel, DJ Foster, AV Kel’in, I Zlatev, A Bisbe, M Jayaraman, ...
Journal of the American Chemical Society 139 (25), 8537-8546, 2017
Efficient solid-phase chemical synthesis of 5′-triphosphates of DNA, RNA, and their analogues
I Zlatev, T Lavergne, F Debart, JJ Vasseur, M Manoharan, F Morvan
Organic letters 12 (10), 2190-2193, 2010
Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
MM Janas, I Zlatev, J Liu, Y Jiang, SA Barros, JE Sutherland, WP Davis, ...
Nucleic acids research 47 (7), 3306-3320, 2019
4′-C-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing
E Malek-Adamian, DC Guenther, S Matsuda, S Martínez-Montero, I Zlatev, ...
Journal of the American Chemical Society 139 (41), 14542-14555, 2017
A Glu-urea-Lys ligand-conjugated lipid nanoparticle/siRNA system inhibits androgen receptor expression in vivo
JB Lee, K Zhang, YYC Tam, J Quick, YK Tam, PJC Lin, S Chen, Y Liu, ...
Molecular Therapy-Nucleic Acids 5, 2016
The nonclinical disposition and pharmacokinetic/pharmacodynamic properties of N-Acetylgalactosamine–conjugated small interfering RNA are highly predictable and build confidence …
R McDougall, D Ramsden, S Agarwal, S Agarwal, K Aluri, M Arciprete, ...
Drug Metabolism and Disposition 50 (6), 781-797, 2022
Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates
RG Parmar, CR Brown, S Matsuda, JLS Willoughby, CS Theile, ...
Journal of medicinal chemistry 61 (3), 734-744, 2018
δ-Di-carboxybutyl phosphoramidate of 2′-deoxycytidine-5′-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase
I Zlatev, A Giraut, F Morvan, P Herdewijn, JJ Vasseur
Bioorganic & medicinal chemistry 17 (19), 7008-7014, 2009
Solid‐Phase Chemical Synthesis of 5′‐Triphosphate DNA, RNA, and Chemically Modified Oligonucleotides
I Zlatev, M Manoharan, JJ Vasseur, F Morvan
Current protocols in nucleic acid chemistry 50 (1), 1.28. 1-1.28. 16, 2012
Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo
H Jahns, N Taneja, JLS Willoughby, M Akabane-Nakata, CR Brown, ...
Nucleic acids research 50 (3), 1221-1240, 2022
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