Lydia Castelli
Lydia Castelli
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Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies
NP Hoyle, LM Castelli, SG Campbell, LEA Holmes, MP Ashe
The Journal of cell biology 179 (1), 65-74, 2007
Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
A Varcianna, MA Myszczynska, LM Castelli, B O'Neill, Y Kim, J Talbot, ...
EBioMedicine 40, 626-635, 2019
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
GM Hautbergue, LM Castelli, L Ferraiuolo, A Sanchez-Martinez, ...
Nature communications 8 (1), 16063, 2017
Identification and functional characterization of effectors in expressed sequence tags from various life cycle stages of the potato cyst nematode Globodera pallida
JT Jones, A Kumar, LA Pylypenko, A Thirugnanasambandam, L Castelli, ...
Molecular Plant Pathology 10 (6), 815-828, 2009
Mapping QTLs for resistance to the cyst nematode Globodera pallida derived from the wild potato species Solanum vernei
G Bryan, K McLean, J Bradshaw, W De Jong, M Phillips, L Castelli, ...
Theoretical and Applied Genetics 105, 68-77, 2002
Global mRNA selection mechanisms for translation initiation
J Costello, LM Castelli, W Rowe, CJ Kershaw, D Talavera, ...
Genome biology 16, 1-21, 2015
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
SP Allen, B Hall, LM Castelli, L Francis, R Woof, AP Siskos, E Kouloura, ...
Brain 142 (3), 586-605, 2019
Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up …
LM Castelli, J Lui, SG Campbell, W Rowe, LAH Zeef, LEA Holmes, ...
Molecular biology of the cell 22 (18), 3379-3393, 2011
Granules harboring translationally active mRNAs provide a platform for P-body formation following stress
J Lui, LM Castelli, M Pizzinga, CE Simpson, NP Hoyle, KL Bailey, ...
Cell reports 9 (3), 944-954, 2014
Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis
J Cooper-Knock, T Moll, T Ramesh, L Castelli, A Beer, H Robins, I Fox, ...
Cell reports 26 (9), 2298-2306. e5, 2019
Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins
AG Cridge, LM Castelli, JB Smirnova, JN Selley, W Rowe, SJ Hubbard, ...
Nucleic acids research 38 (22), 8039-8050, 2010
Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features
MP Shaw, A Higginbottom, A McGown, LM Castelli, E James, ...
Acta neuropathologica communications 6, 1-16, 2018
Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p
CJ Kershaw, JL Costello, D Talavera, W Rowe, LM Castelli, PFG Sims, ...
Scientific reports 5 (1), 15518, 2015
The 4E-BP Caf20p mediates both eIF4E-dependent and independent repression of translation
LM Castelli, D Talavera, CJ Kershaw, SS Mohammad-Qureshi, ...
PLoS genetics 11 (5), e1005233, 2015
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease
N Gatto, C Dos Santos Souza, AC Shaw, SM Bell, MA Myszczynska, ...
Aging Cell 20 (1), e13281, 2021
The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response
CJ Kershaw, JL Costello, LM Castelli, D Talavera, W Rowe, PFG Sims, ...
PLoS genetics 11 (1), e1004903, 2015
New sources of resistance to the potato cyst nematodes Globodera pallida and G. rostochiensis in the Commonwealth Potato Collection
L Castelli, G Ramsay, G Bryan, SJ Neilson, MS Phillips
Euphytica 129, 377-386, 2003
Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses
JL Costello, CJ Kershaw, LM Castelli, D Talavera, W Rowe, PFG Sims, ...
Genome biology 18, 1-18, 2017
Puf3p induces translational repression of genes linked to oxidative stress
W Rowe, CJ Kershaw, LM Castelli, JL Costello, MP Ashe, CM Grant, ...
Nucleic acids research 42 (2), 1026-1041, 2013
Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae
NE Egbe, TO Dornelles, CM Paget, LM Castelli, MP Ashe
Microbial cell 4 (9), 294, 2017
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