Lydia Castelli
Lydia Castelli
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Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies
NP Hoyle, LM Castelli, SG Campbell, LEA Holmes, MP Ashe
The Journal of cell biology 179 (1), 65-74, 2007
Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
A Varcianna, MA Myszczynska, LM Castelli, B O'Neill, Y Kim, J Talbot, ...
EBioMedicine 40, 626-635, 2019
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
GM Hautbergue, LM Castelli, L Ferraiuolo, A Sanchez-Martinez, ...
Nature communications 8 (1), 16063, 2017
Mapping QTLs for resistance to the cyst nematode Globodera pallida derived from the wild potato species Solanum vernei
G Bryan, K McLean, J Bradshaw, W De Jong, M Phillips, L Castelli, ...
Theoretical and Applied Genetics 105, 68-77, 2002
Identification and functional characterization of effectors in expressed sequence tags from various life cycle stages of the potato cyst nematode Globodera pallida
JT Jones, A Kumar, LA Pylypenko, A Thirugnanasambandam, L Castelli, ...
Molecular Plant Pathology 10 (6), 815-828, 2009
Global mRNA selection mechanisms for translation initiation
J Costello, LM Castelli, W Rowe, CJ Kershaw, D Talavera, ...
Genome biology 16 (1), 1-21, 2015
Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up …
LM Castelli, J Lui, SG Campbell, W Rowe, LAH Zeef, LEA Holmes, ...
Molecular biology of the cell 22 (18), 3379-3393, 2011
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
SP Allen, B Hall, LM Castelli, L Francis, R Woof, AP Siskos, E Kouloura, ...
Brain 142 (3), 586-605, 2019
Granules harboring translationally active mRNAs provide a platform for P-body formation following stress
J Lui, LM Castelli, M Pizzinga, CE Simpson, NP Hoyle, KL Bailey, ...
Cell reports 9 (3), 944-954, 2014
Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins
AG Cridge, LM Castelli, JB Smirnova, JN Selley, W Rowe, SJ Hubbard, ...
Nucleic acids research 38 (22), 8039-8050, 2010
Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis
J Cooper-Knock, T Moll, T Ramesh, L Castelli, A Beer, H Robins, I Fox, ...
Cell reports 26 (9), 2298-2306. e5, 2019
Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features
MP Shaw, A Higginbottom, A McGown, LM Castelli, E James, ...
Acta neuropathologica communications 6 (1), 1-16, 2018
Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p
CJ Kershaw, JL Costello, D Talavera, W Rowe, LM Castelli, PFG Sims, ...
Scientific reports 5 (1), 15518, 2015
The 4E-BP Caf20p mediates both eIF4E-dependent and independent repression of translation
LM Castelli, D Talavera, CJ Kershaw, SS Mohammad-Qureshi, ...
PLoS genetics 11 (5), e1005233, 2015
The yeast La related protein Slf1p is a key activator of translation during the oxidative stress response
CJ Kershaw, JL Costello, LM Castelli, D Talavera, W Rowe, PFG Sims, ...
PLoS genetics 11 (1), e1004903, 2015
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease
N Gatto, C Dos Santos Souza, AC Shaw, SM Bell, MA Myszczynska, ...
Aging Cell 20 (1), e13281, 2021
New sources of resistance to the potato cyst nematodes Globodera pallida and G. rostochiensis in the Commonwealth Potato Collection
L Castelli, G Ramsay, G Bryan, SJ Neilson, MS Phillips
Euphytica 129, 377-386, 2003
Puf3p induces translational repression of genes linked to oxidative stress
W Rowe, CJ Kershaw, LM Castelli, JL Costello, MP Ashe, CM Grant, ...
Nucleic acids research 42 (2), 1026-1041, 2013
Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses
JL Costello, CJ Kershaw, LM Castelli, D Talavera, W Rowe, PFG Sims, ...
Genome biology 18, 1-18, 2017
Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae
NE Egbe, TO Dornelles, CM Paget, LM Castelli, MP Ashe
Microbial cell 4 (9), 294, 2017
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