Zhong-Yin Zhang
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PTP1B as a drug target: recent developments in PTP1B inhibitor discovery
S Zhang, ZY Zhang
Drug discovery today 12 (9-10), 373-381, 2007
Structural and functional analysis of the costimulatory receptor programmed death-1
X Zhang, JCD Schwartz, X Guo, S Bhatia, E Cao, L Chen, ZY Zhang, ...
Immunity 20 (3), 337-347, 2004
Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development
ZY Zhang
Annual review of pharmacology and toxicology 42 (1), 209-234, 2002
Regulation of PTP1B via glutathionylation of the active site cysteine 215
WC Barrett, JP DeGnore, S König, HM Fales, YF Keng, ZY Zhang, MB Yim, ...
Biochemistry 38 (20), 6699-6705, 1999
Protein tyrosine phosphatases: prospects for therapeutics
ZY Zhang
Current opinion in chemical biology 5 (4), 416-423, 2001
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate
JA Stuckey, HL Schubert, EB Fauman, ZY Zhang, JE Dixon, MA Saper
Nature 370 (6490), 571-575, 1994
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design
YA Puius, Y Zhao, M Sullivan, DS Lawrence, SC Almo, ZY Zhang
Proceedings of the National Academy of Sciences 94 (25), 13420-13425, 1997
Roles of superoxide radical anion in signal transduction mediated by reversible regulation of protein-tyrosine phosphatase 1B
WC Barrett, JP DeGnore, YF Keng, ZY Zhang, MB Yim, PB Chock
Journal of Biological Chemistry 274 (49), 34543-34546, 1999
Leptin and insulin act on POMC neurons to promote the browning of white fat
GT Dodd, S Decherf, K Loh, SE Simonds, F Wiede, E Balland, TL Merry, ...
Cell 160 (1), 88-104, 2015
Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis
ZY Zhang
Critical reviews in biochemistry and molecular biology 33 (1), 1-52, 1998
Dissecting the catalytic mechanism of protein-tyrosine phosphatases.
ZY Zhang, Y Wang, JE Dixon
Proceedings of the National Academy of Sciences 91 (5), 1624-1627, 1994
Protein tyrosine phosphatases as potential therapeutic targets
R He, Z Yu, R Zhang, Z Zhang
Acta pharmacologica sinica 35 (10), 1227-1246, 2014
Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402
ZY Zhang, JE Dixon
Biochemistry 32 (36), 9340-9345, 1993
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+ CD25+ regulatory T-cells of type 1 diabetic subjects
SA Long, K Cerosaletti, PL Bollyky, M Tatum, H Shilling, S Zhang, ...
diabetes 59 (2), 407-415, 2010
PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity
ZY Zhang, SY Lee
Expert opinion on investigational drugs 12 (2), 223-233, 2003
Substrate specificity of the protein tyrosine phosphatases.
ZY Zhang, AM Thieme-Sefler, D Maclean, DJ McNamara, EM Dobrusin, ...
Proceedings of the National Academy of Sciences 90 (10), 4446-4450, 1993
Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure
K Shen, YF Keng, L Wu, XL Guo, DS Lawrence, ZY Zhang
Journal of Biological Chemistry 276 (50), 47311-47319, 2001
Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase.
ZY Zhang, JC Clemens, HL Schubert, JA Stuckey, MW Fischer, DM Hume, ...
Journal of Biological Chemistry 267 (33), 23759-23766, 1992
The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases
B Zhou, ZX Wang, YU Zhao, DL Brautigan, ZY Zhang
Journal of Biological Chemistry 277 (35), 31818-31825, 2002
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents
B Zhou, Y He, X Zhang, J Xu, Y Luo, Y Wang, SG Franzblau, Z Yang, ...
Proceedings of the National Academy of Sciences 107 (10), 4573-4578, 2010
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