Bon-Kyoung Koo

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Hans CleversHubrecht Institute - UtrechtVerified email at hubrecht.eu
Young-yun KongProfessor of biological sciences, Seoul National UniversityVerified email at snu.ac.kr
Daniel E StangeTU DresdenVerified email at uniklinikum-dresden.de
Ki-Jun YoonKorea Advanced Institute of Science and Technology (KAIST)Verified email at kaist.ac.kr
Hyun-Woo JeongMax-Planck Institute for Molecular BiomedicineVerified email at mpi-muenster.mpg.de
Benjamin D SimonsUniversity of CambridgeVerified email at cam.ac.uk
Shabaz MohammedAssociate Professor of Proteomics, University of OxfordVerified email at bioch.ox.ac.uk
Albert J. R. HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center and Utrecht UniversityVerified email at uu.nl
Edwin CuppenHoogleraar Humane GeneticaVerified email at umcutrecht.nl
Madelon MauriceProfessor of Molecular Cell Biology, Center for Molecular Medicine, UMC UtrechtVerified email at umcutrecht.nl
Teck Yew LowUKM Medical Molecular Biology InstituteVerified email at ppukm.ukm.edu.my
Mustata RCScientist, Stemcell Technologies UKVerified email at stemcell.com
Alexander van OudenaardenHubrecht InstituteVerified email at hubrecht.eu
Prof Nick BarkerA-STAR Institute of Molecular and Cellular Biology, SingaporeVerified email at imcb.a-star.edu.sg
Peter J. PetersProfessor of NanoBiology, Maastricht University, The NetherlandsVerified email at maastrichtuniversity.nl
Gerald SchwankUniversity ZurichVerified email at pharma.uzh.ch
Inha HeoHubrecht InstituteVerified email at hubrecht.eu
Shalev ItzkovitzProfessor, Weizmann Institute of ScienceVerified email at weizmann.ac.il
Javier MuñozBiocruces BizkaiaVerified email at osakidetza.eus
Josef PenningerLife Sciences Institute, University of British Columbia / IMBA Institut für MolekulareVerified email at imba.oeaw.ac.at

Bon-Kyoung Koo

Institute of Molecular Biotechnology (IMBA) - The Austrian Academy of Sciences

Verified email at imba.oeaw.ac.at - Homepage

Intestine Stem cell Wnt Organoids CRISPR/Cas


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Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients G Schwank, BK Koo, V Sasselli, JF Dekkers, I Heo, T Demircan, N Sasaki, ... Cell stem cell 13 (6), 653-658, 2013	1451	2013
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ... Nature 476 (7360), 293-297, 2011	1290	2011
Human organoids: model systems for human biology and medicine J Kim, BK Koo, JA Knoblich Nature Reviews Molecular Cell Biology 21 (10), 571-584, 2020	969	2020
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening L Broutier, G Mastrogiovanni, MMA Verstegen, HE Francies, LM Gavarró, ... Nature medicine 23 (12), 1424-1435, 2017	920	2017
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors BK Koo, M Spit, I Jordens, TY Low, DE Stange, M Van De Wetering, ... Nature 488 (7413), 665-669, 2012	901	2012
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers J Muñoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ... The EMBO journal 31 (14), 3079-3091, 2012	770	2012
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation L Broutier, A Andersson-Rolf, CJ Hindley, SF Boj, H Clevers, BK Koo, ... Nature protocols 11 (9), 1724-1743, 2016	536	2016
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium DE Stange, BK Koo, M Huch, G Sibbel, O Basak, A Lyubimova, P Kujala, ... Cell 155 (2), 357-368, 2013	475	2013
Modeling mouse and human development using organoid cultures M Huch, BK Koo Development 142 (18), 3113-3125, 2015	453	2015
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium MY Turco, L Gardner, J Hughes, T Cindrova-Davies, MJ Gomez, L Farrell, ... Nature cell biology 19 (5), 568-577, 2017	430	2017
Controlled gene expression in primary Lgr5 organoid cultures BK Koo, DE Stange, T Sato, W Karthaus, HF Farin, M Huch, JH Van Es, ... Nature methods 9 (1), 81-83, 2012	331	2012
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal JH van Es, A Haegebarth, P Kujala, S Itzkovitz, BK Koo, SF Boj, J Korving, ... Molecular and cellular biology 32 (10), 1918-1927, 2012	276	2012
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch BK Koo, HS Lim, R Song, MJ Yoon, KJ Yoon, JS Moon, YW Kim, M Kwon, ... Oxford University Press for The Company of Biologists Limited 132 (15), 3459 …, 2005	271	2005
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts J Schuijers, JP Junker, M Mokry, P Hatzis, BK Koo, V Sasselli, ... Cell stem cell 16 (2), 158-170, 2015	253	2015
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response J Heijmans, JFL de Jeude, BK Koo, SL Rosekrans, MCB Wielenga, ... Cell reports 3 (4), 1128-1139, 2013	238	2013
A crucial role of WW45 in developing epithelial tissues in the mouse JH Lee, TS Kim, TH Yang, BK Koo, SP Oh, KP Lee, HJ Oh, SH Lee, ... The EMBO journal 27 (8), 1231-1242, 2008	219	2008
Inflammatory signals induce AT2 cell-derived damage-associated transient progenitors that mediate alveolar regeneration J Choi, JE Park, G Tsagkogeorga, M Yanagita, BK Koo, N Han, JH Lee Cell stem cell 27 (3), 366-382. e7, 2020	211	2020
DNA methylation and transcription patterns in intestinal epithelial cells from pediatric patients with inflammatory bowel diseases differentiate disease subtypes and associate … KJ Howell, J Kraiczy, KM Nayak, M Gasparetto, A Ross, C Lee, TN Mak, ... Gastroenterology 154 (3), 585-598, 2018	209	2018
Divergent routes toward Wnt and R-spondin niche independency during human gastric carcinogenesis K Nanki, K Toshimitsu, A Takano, M Fujii, M Shimokawa, Y Ohta, ... Cell 174 (4), 856-869. e17, 2018	206	2018
Human gastric cancer modelling using organoids T Seidlitz, SR Merker, A Rothe, F Zakrzewski, C von Neubeck, ... Gut 68 (2), 207-217, 2019	203	2019

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