Ruenn Chai LAI
Ruenn Chai LAI
Institute of Medical Biology
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Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
RC Lai, F Arslan, MM Lee, NSK Sze, A Choo, TS Chen, M Salto-Tellez, ...
Stem cell research 4 (3), 214-222, 2010
Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse …
F Arslan, RC Lai, MB Smeets, L Akeroyd, A Choo, ENE Aguor, L Timmers, ...
Stem cell research 10 (3), 301-312, 2013
Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery
RWY Yeo, RC Lai, B Zhang, SS Tan, Y Yin, BJ Teh, SK Lim
Advanced drug delivery reviews 65 (3), 336-341, 2013
Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs
TS Chen, RC Lai, MM Lee, ABH Choo, CN Lee, SK Lim
Nucleic acids research 38 (1), 215-224, 2010
MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity
S Zhang, SJ Chuah, RC Lai, JHP Hui, SK Lim, WS Toh
Biomaterials 156, 16-27, 2018
Mesenchymal stem cells secrete immunologically active exosomes
B Zhang, Y Yin, RC Lai, SS Tan, ABH Choo, SK Lim
Stem cells and development 23 (11), 1233-1244, 2014
Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
RC Lai, TS Chen, SK Lim
Regenerative medicine 6 (4), 481-492, 2011
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes
JE Park, HS Tan, A Datta, RC Lai, H Zhang, W Meng, SK Lim, SK Sze
Molecular & cellular proteomics 9 (6), 1085-1099, 2010
Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration
S Zhang, WC Chu, RC Lai, SK Lim, JHP Hui, WS Toh
Osteoarthritis and cartilage 24 (12), 2135-2140, 2016
Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models
CY Tan, RC Lai, W Wong, YY Dan, SK Lim, HK Ho
Stem cell research & therapy 5, 1-14, 2014
Mesenchymal stem cell exosomes
RC Lai, RWY Yeo, SK Lim
Seminars in cell & developmental biology 40, 82-88, 2015
Exosomes for drug delivery—a novel application for the mesenchymal stem cell
RC Lai, RWY Yeo, KH Tan, SK Lim
Biotechnology advances 31 (5), 543-551, 2013
Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome
RC Lai, SS Tan, BJ Teh, SK Sze, F Arslan, DP De Kleijn, A Choo, SK Lim
International journal of proteomics 2012, 2012
Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction
L Timmers, SK Lim, IE Hoefer, F Arslan, RC Lai, AAM van Oorschot, ...
Stem cell research 6 (3), 206-214, 2011
MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment
WS Toh, RC Lai, JHP Hui, SK Lim
Seminars in cell & developmental biology 67, 56-64, 2017
Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications
KW Witwer, BWM Van Balkom, S Bruno, A Choo, M Dominici, M Gimona, ...
Journal of extracellular vesicles 8 (1), 1609206, 2019
Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs
TS Chen, F Arslan, Y Yin, SS Tan, RC Lai, ABH Choo, J Padmanabhan, ...
Journal of translational medicine 9 (1), 1-10, 2011
MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis
S Zhang, KYW Teo, SJ Chuah, RC Lai, SK Lim, WS Toh
Biomaterials 200, 35-47, 2019
Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells
SK Sze, DPV de Kleijn, RC Lai, EKW Tan, H Zhao, KS Yeo, TY Low, ...
Molecular & Cellular Proteomics 6 (10), 1680-1689, 2007
MSC exosome works through a protein-based mechanism of action
WS Toh, RC Lai, B Zhang, SK Lim
Biochemical Society Transactions 46 (4), 843-853, 2018
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