Titus M. Franzmann
Titus M. Franzmann
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A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation
A Patel, HO Lee, L Jawerth, S Maharana, M Jahnel, MY Hein, S Stoynov, ...
Cell 162 (5), 1066-1077, 2015
Some like it hot: the structure and function of small heat-shock proteins
M Haslbeck, T Franzmann, D Weinfurtner, J Buchner
Nature structural & molecular biology 12 (10), 842-846, 2005
RNA buffers the phase separation behavior of prion-like RNA binding proteins
S Maharana, J Wang, DK Papadopoulos, D Richter, A Pozniakovsky, ...
Science 360 (6391), 918-921, 2018
Phase separation of a yeast prion protein promotes cellular fitness
TM Franzmann, M Jahnel, A Pozniakovsky, J Mahamid, AS Holehouse, ...
Science 359 (6371), eaao5654, 2018
RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation
J Guillén-Boixet, A Kopach, AS Holehouse, S Wittmann, M Jahnel, ...
Cell 181 (2), 346-361. e17, 2020
An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
D Mateju, TM Franzmann, A Patel, A Kopach, EE Boczek, S Maharana, ...
The EMBO journal 36 (12), 1669-1687, 2017
A pH-driven transition of the cytoplasm from a fluid-to a solid-like state promotes entry into dormancy
MC Munder, D Midtvedt, T Franzmann, E Nuske, O Otto, M Herbig, ...
elife 5, e09347, 2016
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
G Krainer, TJ Welsh, JA Joseph, P St George-Hyslop, AA Hyman, ...
Biophysical Journal 120 (3), 28a, 2021
Protein condensates as aging Maxwell fluids
L Jawerth, E Fischer-Friedrich, S Saha, J Wang, T Franzmann, X Zhang, ...
Science 370 (6522), 1317-1323, 2020
A user’s guide for phase separation assays with purified proteins
S Alberti, S Saha, JB Woodruff, TM Franzmann, J Wang, AA Hyman
Journal of molecular biology 430 (23), 4806-4820, 2018
Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior
TM Franzmann, S Alberti
Journal of Biological Chemistry 294 (18), 7128-7136, 2019
Different material states of Pub1 condensates define distinct modes of stress adaptation and recovery
S Kroschwald, MC Munder, S Maharana, TM Franzmann, D Richter, ...
Cell reports 23 (11), 3327-3339, 2018
Condensation of Ded1p promotes a translational switch from housekeeping to stress protein production
C Iserman, CD Altamirano, C Jegers, U Friedrich, T Zarin, AW Fritsch, ...
Cell 181 (4), 818-831. e19, 2020
The eye lens chaperone α-crystallin forms defined globular assemblies
J Peschek, N Braun, TM Franzmann, Y Georgalis, M Haslbeck, ...
Proceedings of the National Academy of Sciences 106 (32), 13272-13277, 2009
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions
M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, ...
Proceedings of the National Academy of Sciences 119 (28), e2202222119, 2022
Protein phase separation as a stress survival strategy
TM Franzmann, S Alberti
Cold Spring Harbor perspectives in biology 11 (6), a034058, 2019
Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein Hsp26
HE White, EV Orlova, S Chen, L Wang, A Ignatiou, B Gowen, T Stromer, ...
Structure 14 (7), 1197-1204, 2006
Activation of the chaperone Hsp26 is controlled by the rearrangement of its thermosensor domain
TM Franzmann, P Menhorn, S Walter, J Buchner
Molecular cell 29 (2), 207-216, 2008
Protein refolding by pH-triggered chaperone binding and release
TL Tapley, TM Franzmann, S Chakraborty, U Jakob, JCA Bardwell
Proceedings of the national Academy of Sciences 107 (3), 1071-1076, 2010
The activation mechanism of Hsp26 does not require dissociation of the oligomer
TM Franzmann, M Wühr, K Richter, S Walter, J Buchner
Journal of molecular biology 350 (5), 1083-1093, 2005
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