| Kynurenines in the mammalian brain: when physiology meets pathology R Schwarcz, JP Bruno, PJ Muchowski, HQ Wu Nature Reviews Neuroscience 13 (7), 465-477, 2012 | 1458 | 2012 |
| Modulation of neurodegeneration by molecular chaperones PJ Muchowski, JL Wacker Nature Reviews Neuroscience 6 (1), 11-22, 2005 | 1290 | 2005 |
| Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils PJ Muchowski, G Schaffar, A Sittler, EE Wanker, MK Hayer-Hartl, FU Hartl Proceedings of the National Academy of Sciences 97 (14), 7841-7846, 2000 | 826 | 2000 |
| Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration D Zwilling, SY Huang, KV Sathyasaikumar, FM Notarangelo, P Guidetti, ... Cell 145 (6), 863-874, 2011 | 545 | 2011 |
| Yeast genes that enhance the toxicity of a mutant huntingtin fragment or α-synuclein S Willingham, TF Outeiro, MJ DeVit, SL Lindquist, PJ Muchowski Science 302 (5651), 1769-1772, 2003 | 539 | 2003 |
| Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models IH Cheng, K Scearce-Levie, J Legleiter, JJ Palop, H Gerstein, N Bien-Ly, ... Journal of Biological Chemistry 282 (33), 23818-23828, 2007 | 519 | 2007 |
| Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ... Human molecular genetics 15 (18), 2743-2751, 2006 | 493 | 2006 |
| A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease F Giorgini, P Guidetti, QV Nguyen, SC Bennett, PJ Muchowski Nature genetics 37 (5), 526-531, 2005 | 420 | 2005 |
| Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones? PJ Muchowski Neuron 35 (1), 9-12, 2002 | 413 | 2002 |
| Flanking sequences profoundly alter polyglutamine toxicity in yeast ML Duennwald, S Jagadish, PJ Muchowski, S Lindquist Proceedings of the National Academy of Sciences 103 (29), 11045-11050, 2006 | 364 | 2006 |
| Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer JL Wacker, MH Zareie, H Fong, M Sarikaya, PJ Muchowski Nature structural & molecular biology 11 (12), 1215-1222, 2004 | 353 | 2004 |
| Small heat-shock proteins and their potential role in human disease JI Clark, PJ Muchowski Current opinion in structural biology 10 (1), 52-59, 2000 | 341 | 2000 |
| The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease S Campesan, EW Green, C Breda, KV Sathyasaikumar, PJ Muchowski, ... Current Biology 21 (11), 961-966, 2011 | 279 | 2011 |
| Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo J Legleiter, E Mitchell, GP Lotz, E Sapp, C Ng, M DiFiglia, LM Thompson, ... Journal of Biological Chemistry 285 (19), 14777-14790, 2010 | 253 | 2010 |
| Identifying polyglutamine protein species in situ that best predict neurodegeneration J Miller, M Arrasate, E Brooks, CP Libeu, J Legleiter, D Hatters, J Curtis, ... Nature chemical biology 7 (12), 925-934, 2011 | 242 | 2011 |
| ATP-enhanced molecular chaperone functions of the small heat shock protein human αB crystallin PJ Muchowski, JI Clark Proceedings of the National Academy of Sciences 95 (3), 1004-1009, 1998 | 198 | 1998 |
| The cardiomyopathy and lens cataract mutation in αB-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro M Der Perng, PJ Muchowski, P van den IJssel, GJS Wu, AM Hutcheson, ... Journal of Biological Chemistry 274 (47), 33235-33243, 1999 | 197 | 1999 |
| Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease K Trinh, K Moore, PD Wes, PJ Muchowski, J Dey, L Andrews, LJ Pallanck Journal of Neuroscience 28 (2), 465-472, 2008 | 180 | 2008 |
| Of mice, rats and men: revisiting the quinolinic acid hypothesis of Huntington's disease R Schwarcz, P Guidetti, KV Sathyasaikumar, PJ Muchowski Progress in neurobiology 90 (2), 230-245, 2010 | 179 | 2010 |
| A network of protein interactions determines polyglutamine toxicity ML Duennwald, S Jagadish, F Giorgini, PJ Muchowski, S Lindquist Proceedings of the National Academy of Sciences 103 (29), 11051-11056, 2006 | 178 | 2006 |
