Stephanie Wilhelm
Stephanie Wilhelm
Chair of Proteomics and Bioanalytics, TU Munich
Verified email at
Cited by
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The target landscape of clinical kinase drugs
S Klaeger, S Heinzlmeir, M Wilhelm, H Polzer, B Vick, PA Koenig, ...
Science 358 (6367), eaan4368, 2017
Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS
Y Bian, R Zheng, FP Bayer, C Wong, YC Chang, C Meng, DP Zolg, ...
Nature communications 11 (1), 157, 2020
Optimized chemical proteomics assay for kinase inhibitor profiling
G Médard, F Pachl, B Ruprecht, S Klaeger, S Heinzlmeir, D Helm, H Qiao, ...
Journal of proteome research 14 (3), 1574-1586, 2015
Chemical proteomics reveals ferrochelatase as a common off-target of kinase inhibitors
S Klaeger, B Gohlke, J Perrin, V Gupta, S Heinzlmeir, D Helm, H Qiao, ...
ACS chemical biology 11 (5), 1245-1254, 2016
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase
B Adhikari, J Bozilovic, M Diebold, JD Schwarz, J Hofstetter, M Schröder, ...
Nature chemical biology 16 (11), 1179-1188, 2020
The formation of a camalexin biosynthetic metabolon
S Mucha, S Heinzlmeir, V Kriechbaumer, B Strickland, C Kirchhelle, ...
The Plant Cell 31 (11), 2697-2710, 2019
Proteome activity landscapes of tumor cell lines determine drug responses
M Frejno, C Meng, B Ruprecht, T Oellerich, S Scheich, K Kleigrewe, ...
Nature communications 11 (1), 3639, 2020
Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs
S Heinzlmeir, D Kudlinzki, S Sreeramulu, S Klaeger, SL Gande, V Linhard, ...
ACS chemical biology 11 (12), 3400-3411, 2016
Pharmacoproteomic characterisation of human colon and rectal cancer
M Frejno, R Zenezini Chiozzi, M Wilhelm, H Koch, R Zheng, S Klaeger, ...
Molecular systems biology 13 (11), 951, 2017
Design, synthesis, and evaluation of WD-repeat-containing protein 5 (WDR5) degraders
A Dölle, B Adhikari, A Krämer, J Weckesser, N Berner, LM Berger, ...
Journal of medicinal chemistry 64 (15), 10682-10710, 2021
Evaluation of kinase activity profiling using chemical proteomics
B Ruprecht, J Zecha, S Heinzlmeir, G Medard, S Lemeer, B Kuster
ACS chemical biology 10 (12), 2743-2752, 2015
DENEDDYLASE1 Deconjugates NEDD8 from Non-Cullin Protein Substrates in Arabidopsis thaliana
J Mergner, S Heinzlmeir, B Kuster, C Schwechheimer
The Plant Cell 27 (3), 741-753, 2015
Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
B Hoermann, T Kokot, D Helm, S Heinzlmeir, JE Chojnacki, T Schubert, ...
Nature Communications 11 (1), 3583, 2020
Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib
RC Montenegro, A Howarth, A Ceroni, V Fedele, B Farran, FP Mesquita, ...
Oncotarget 11 (5), 535, 2020
Decrypting drug actions and protein modifications by dose-and time-resolved proteomics
J Zecha, FP Bayer, S Wiechmann, J Woortman, N Berner, J Müller, ...
Science 380 (6640), 93-101, 2023
Increased pancreatic protease activity in response to antibiotics impairs gut barrier and triggers colitis
H Yoon, M Schaubeck, I Lagkouvardos, A Blesl, S Heinzlmeir, H Hahne, ...
Cellular and Molecular Gastroenterology and Hepatology 6 (3), 370-388. e3, 2018
Chemoproteomics‐aided medicinal chemistry for the discovery of EPHA2 inhibitors
S Heinzlmeir, J Lohse, T Treiber, D Kudlinzki, V Linhard, SL Gande, ...
ChemMedChem 12 (12), 999-1011, 2017
NVP‐BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family
A Tröster, S Heinzlmeir, BT Berger, SL Gande, K Saxena, S Sreeramulu, ...
ChemMedChem 13 (16), 1629-1633, 2018
Chemoproteomic selectivity profiling of PIKK and PI3K kinase inhibitors
M Reinecke, B Ruprecht, S Poser, S Wiechmann, M Wilhelm, ...
ACS Chemical Biology 14 (4), 655-664, 2019
New affinity probe targeting VEGF receptors for kinase inhibitor selectivity profiling by chemical proteomics
X Ku, S Heinzlmeir, D Helm, G Médard, B Kuster
Journal of proteome research 13 (5), 2445-2452, 2014
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