Prof. Dr. Steven Verhelst
Prof. Dr. Steven Verhelst
University of Leuven, Belgium & Leibniz Institute ISAS, Germany
Verified email at - Homepage
Cited by
Cited by
Tagging and detection strategies for activity-based proteomics
AM Sadaghiani, SHL Verhelst, M Bogyo
Current opinion in chemical biology 11 (1), 20-28, 2007
Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
GP Shi, RAR Bryant, R Riese, S Verhelst, C Driessen, Z Li, D Bromme, ...
The Journal of experimental medicine 191 (7), 1177-1186, 2000
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
M Bogyo, S Verhelst, V Bellingard-Dubouchaud, S Toba, D Greenbaum
Chemistry & biology 7 (1), 27-38, 2000
ATP13A2 deficiency disrupts lysosomal polyamine export
S van Veen, S Martin, C Van den Haute, V Benoy, J Lyons, R Vanhoutte, ...
Nature 578 (7795), 419-424, 2020
A mild chemically cleavable linker system for functional proteomic applications
SHL Verhelst, M Fonovic, M Bogyo
Angew. Chem. Int. Ed 46 (8), 1284-1286, 2007
Activity‐based probes for the study of proteases: recent advances and developments
S Serim, U Haedke, SHL Verhelst
ChemMedChem 7 (7), 1146-1159, 2012
The structural basis for catalysis and substrate specificity of a rhomboid protease
KR Vinothkumar, K Strisovsky, A Andreeva, Y Christova, S Verhelst, ...
The EMBO journal 29 (22), 3797-3809, 2010
Proteomics evaluation of chemically cleavable activity-based probes
M Fonovic, SHL Verhelst, MT Sorum, M Bogyo
Molecular & Cellular Proteomics 6 (10), 1761-1770, 2007
Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique
R Mnatsakanyan, S Markoutsa, K Walbrunn, A Roos, SHL Verhelst, ...
Nature communications 10 (1), 2195, 2019
Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases
AM Sadaghiani, SHL Verhelst, V Gocheva, K Hill, E Majerova, S Stinson, ...
Chemistry & biology 14 (5), 499-511, 2007
Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase
F Schlauderer, K Lammens, D Nagel, M Vincendeau, AC Eitelhuber, ...
Angewandte Chemie International Edition 52 (39), 10384-10387, 2013
A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C
F Yuan, SHL Verhelst, G Blum, LM Coussens, M Bogyo
Journal of the American Chemical Society 128 (17), 5616-5617, 2006
Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay
O Vosyka, KR Vinothkumar, EV Wolf, AJ Brouwer, RMJ Liskamp, ...
Proceedings of the National Academy of Sciences 110 (7), 2472-2477, 2013
Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using ‘click chemistry’
F Kaschani, SHL Verhelst, PF Van Swieten, M Verdoes, CS Wong, ...
The Plant Journal 57 (2), 373-385, 2009
A simple and effective cleavable linker for chemical proteomics applications
Y Yang, H Hahne, B Kuster, SHL Verhelst
Molecular & Cellular Proteomics 12 (1), 237-244, 2013
A Short route toward chiral, polyhydroxylated indolizidines and quinolizidines
SHL Verhelst, B Paez Martinez, MSM Timmer, G Lodder, ...
The Journal of Organic Chemistry 68 (25), 9598-9603, 2003
A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile …
SA Beckham, D Piedrafita, CI Phillips, N Samarawickrema, RHP Law, ...
The international journal of biochemistry & cell biology 41 (7), 1601-1612, 2009
Surface plasmon resonance evaluation of various aminoglycoside–RNA hairpin interactions reveals low degree of selectivity
SHL Verhelst, PJA Michiels, GA van der Marel, CAA van Boeckel, ...
ChemBioChem 5 (7), 937-942, 2004
Development of calpain-specific inactivators by screening of positional scanning epoxide libraries
D Cuerrier, T Moldoveanu, RL Campbell, J Kelly, B Yoruk, SHL Verhelst, ...
Journal of biological chemistry 282 (13), 9600-9611, 2007
Design and synthesis of a protein: farnesyltransferase inhibitor based on sugar amino acids
HS Overkleeft, SHL Verhelst, E Pieterman, NJ Meeuwenoord, ...
Tetrahedron letters 40 (21), 4103-4106, 1999
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