| Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104 SN Gates, AL Yokom, JB Lin, ME Jackrel, AN Rizo, NM Kendsersky, ... Science 357 (6348), 273-279, 2017 | 275 | 2017 |
| Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase AN Rizo, JB Lin, SN Gates, E Tse, SM Bart, LM Castellano, F DiMaio, ... Nature communications 10 (1), 2393, 2019 | 106 | 2019 |
| DAXX represents a new type of protein-folding enabler L Huang, T Agrawal, G Zhu, S Yu, L Tao, JB Lin, R Marmorstein, J Shorter, ... Nature 597 (7874), 132-137, 2021 | 84 | 2021 |
| Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis KE Lopez, AN Rizo, E Tse, JB Lin, NW Scull, AC Thwin, AL Lucius, ... Nature structural & molecular biology 27 (5), 406-416, 2020 | 65 | 2020 |
| E. coli ClpA catalyzed polypeptide translocation is allosterically controlled by the protease ClpP JM Miller, J Lin, T Li, AL Lucius Journal of molecular biology 425 (15), 2795-2812, 2013 | 51 | 2013 |
| Mining disaggregase sequence space to safely counter TDP-43, FUS, and α-synuclein proteotoxicity A Tariq, JB Lin, ME Jackrel, CD Hesketh, PJ Carman, KL Mack, ... Cell reports 28 (8), 2080-2095. e6, 2019 | 49 | 2019 |
| Escherichia coli ClpB is a non-processive polypeptide translocase T Li, CL Weaver, J Lin, EC Duran, JM Miller, AL Lucius Biochemical Journal 470 (1), 39-52, 2015 | 49 | 2015 |
| Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain A Tariq, JB Lin, MM Noll, MP Torrente, KL Mack, OH Murillo, ME Jackrel, ... FEMS Yeast Research 18 (5), foy042, 2018 | 43 | 2018 |
| Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution X Ye, J Lin, L Mayne, J Shorter, SW Englander Proceedings of the National Academy of Sciences 116 (15), 7333-7342, 2019 | 30 | 2019 |
| Therapeutic genetic variation revealed in diverse Hsp104 homologs ZM March, K Sweeney, H Kim, X Yan, LM Castellano, ME Jackrel, JB Lin, ... elife 9, e57457, 2020 | 28 | 2020 |
| AAA+ proteins: one motor, multiple ways to work JB Lin, J Shorter, AL Lucius Biochemical Society Transactions 50 (2), 895-906, 2022 | 26 | 2022 |
| Hsp104 and potentiated variants can operate as distinct nonprocessive translocases CL Durie, JB Lin, NW Scull, KL Mack, ME Jackrel, EA Sweeny, ... Biophysical journal 116 (10), 1856-1872, 2019 | 24 | 2019 |
| Structural and kinetic basis for the regulation and potentiation of Hsp104 function X Ye, JB Lin, L Mayne, J Shorter, SW Englander Proceedings of the National Academy of Sciences 117 (17), 9384-9392, 2020 | 23 | 2020 |
| Examination of the dynamic assembly equilibrium for E. coli ClpB JB Lin, AL Lucius Proteins: Structure, Function, and Bioinformatics 83 (11), 2008-2024, 2015 | 22 | 2015 |
| Tuning Hsp104 specificity to selectively detoxify α-synuclein KL Mack, H Kim, EM Barbieri, JB Lin, S Braganza, ME Jackrel, JE DeNizio, ... Molecular cell 83 (18), 3314-3332. e9, 2023 | 19 | 2023 |
| The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate RD Jones, C Enam, R Ibarra, HR Borror, KE Mostoller, EK Fredrickson, ... Molecular Biology of the Cell 31 (3), 221-233, 2020 | 19 | 2020 |
| Examination of ClpB quaternary structure and linkage to nucleotide binding JB Lin, AL Lucius Biophysical Journal 110 (3), 202a, 2016 | 19 | 2016 |
| Examination of polypeptide substrate specificity for Escherichia coli ClpB T Li, J Lin, AL Lucius Proteins: Structure, Function, and Bioinformatics 83 (1), 117-134, 2015 | 19 | 2015 |
| Avidity for polypeptide binding by nucleotide-bound Hsp104 structures CL Weaver, EC Duran, KL Mack, JB Lin, ME Jackrel, EA Sweeny, ... Biochemistry 56 (15), 2071-2075, 2017 | 18 | 2017 |
| Characterization of calmodulin–fas death domain interaction: An integrated experimental and computational study RM Fancy, L Wang, T Napier, J Lin, G Jing, AL Lucius, JM McDonald, ... Biochemistry 53 (16), 2680-2688, 2014 | 15 | 2014 |
James ShorterProfessor of Biochemistry and Biophysics, University of PennsylvaniaVerified email at pennmedicine.upenn.edu
