David Sims
David Sims
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Sequencing depth and coverage: key considerations in genomic analyses
D Sims, I Sudbery, NE Ilott, A Heger, CP Ponting
Nature Reviews Genetics 15 (2), 121-132, 2014
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
AM Farcas, NP Blackledge, I Sudbery, HK Long, JF McGouran, NR Rose, ...
elife 1, e00205, 2012
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly
H Li, J Janssens, M De Waegeneer, SS Kolluru, K Davie, V Gardeux, ...
Science 375 (6584), eabk2432, 2022
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity
I Bajrami, JR Frankum, A Konde, RE Miller, FL Rehman, R Brough, ...
Cancer research 74 (1), 287-297, 2014
Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes
NE Ilott, JA Heward, B Roux, E Tsitsiou, PS Fenwick, L Lenzi, I Goodhead, ...
Nature communications 5 (1), 3979, 2014
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates
HK Long, D Sims, A Heger, NP Blackledge, C Kutter, ML Wright, ...
elife 2, e00348, 2013
High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing
D Sims, AM Mendes-Pereira, J Frankum, D Burgess, MA Cerone, ...
Genome biology 12, 1-13, 2011
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
DJ Ahern, Z Ai, M Ainsworth, C Allan, A Allcock, B Angus, MA Ansari, ...
Cell 185 (5), 916-938. e58, 2022
Functional viability profiles of breast cancer
R Brough, JR Frankum, D Sims, A Mackay, AM Mendes-Pereira, I Bajrami, ...
Cancer discovery 1 (3), 260-273, 2011
De novo point mutations in patients diagnosed with ataxic cerebral palsy
R Parolin Schnekenberg, EM Perkins, JW Miller, WIL Davies, ...
Brain 138 (7), 1817-1832, 2015
Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy
P Rajan, IM Sudbery, MEM Villasevil, E Mui, J Fleming, M Davis, I Ahmad, ...
European urology 66 (1), 32-39, 2014
Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen
AM Mendes-Pereira, D Sims, T Dexter, K Fenwick, I Assiotis, I Kozarewa, ...
Proceedings of the National Academy of Sciences 109 (8), 2730-2735, 2012
Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability
MD Morgan, E Pairo-Castineira, K Rawlik, O Canela-Xandri, J Rees, ...
Nature communications 9 (1), 5271, 2018
SPG7 mutations are a common cause of undiagnosed ataxia
G Pfeffer, A Pyle, H Griffin, J Miller, V Wilson, L Turnbull, K Fawcett, ...
Neurology 84 (11), 1174-1176, 2015
An essential role for the Zn2+ transporter ZIP7 in B cell development
C Anzilotti, DJ Swan, B Boisson, M Deobagkar-Lele, C Oliveira, ...
Nature immunology 20 (3), 350-361, 2019
Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair–deficient cancers
SA Martin, M Hewish, D Sims, CJ Lord, A Ashworth
Cancer research 71 (5), 1836-1848, 2011
Tuning the transcriptional response to hypoxia by inhibiting hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases
MC Chan, NE Ilott, J Schödel, D Sims, A Tumber, K Lippl, DR Mole, ...
Journal of Biological Chemistry 291 (39), 20661-20673, 2016
An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor
N Murugaesu, M Iravani, A Van Weverwijk, A Ivetic, DA Johnson, ...
Cancer discovery 4 (3), 304-317, 2014
Co-transcriptional loading of RNA export factors shapes the human transcriptome
N Viphakone, I Sudbery, L Griffith, CG Heath, D Sims, SA Wilson
Molecular Cell 75 (2), 310-323. e8, 2019
De novo mutations in GRIN1 cause extensive bilateral polymicrogyria
AE Fry, KA Fawcett, N Zelnik, H Yuan, BAN Thompson, L Shemer-Meiri, ...
Brain 141 (3), 698-712, 2018
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