Heike Brötz-Oesterhelt
Heike Brötz-Oesterhelt
Professor for Microbiology, IMIT, University of Tuebingen
Verified email at - Homepage
Cited by
Cited by
Human commensals producing a novel antibiotic impair pathogen colonization
A Zipperer, MC Konnerth, C Laux, A Berscheid, D Janek, C Weidenmaier, ...
Nature 535 (7613), 511-516, 2016
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
H Brötz-Oesterhelt, D Beyer, HP Kroll, R Endermann, C Ladel, ...
Nature medicine 11 (10), 1082-1087, 2005
Towards the sustainable discovery and development of new antibiotics
M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ...
Nature Reviews Chemistry 5 (10), 726-749, 2021
Proteomic approach to understanding antibiotic action
JE Bandow, H Brötz, LIO Leichert, H Labischinski, M Hecker
Antimicrobial agents and chemotherapy 47 (3), 948-955, 2003
Role of lipid‐bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics
H Brötz, M Josten, I Wiedemann, U Schneider, F Götz, G Bierbaum, ...
Molecular microbiology 30 (2), 317-327, 1998
The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II
H Brötz, G Bierbaum, K Leopold, PE Reynolds, HG Sahl
Antimicrobial agents and chemotherapy 42 (1), 154-160, 1998
Small cationic antimicrobial peptides delocalize peripheral membrane proteins
M Wenzel, AI Chiriac, A Otto, D Zweytick, C May, C Schumacher, R Gust, ...
Proceedings of the National Academy of Sciences 111 (14), E1409-E1418, 2014
The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation
H Brötz, G Bierbaum, PE Reynolds, HG Sahl
European Journal of Biochemistry 246 (1), 193-199, 1997
Inducing Secondary Metabolite Production by the Endophytic Fungus Fusarium tricinctum through Coculture with Bacillus subtilis
ARB Ola, D Thomy, D Lai, H Brötz-Oesterhelt, P Proksch
Journal of natural products 76 (11), 2094-2099, 2013
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
BG Lee, EY Park, KE Lee, H Jeon, KH Sung, H Paulsen, ...
Nature structural & molecular biology 17 (4), 471-478, 2010
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
J Kirstein, A Hoffmann, H Lilie, R Schmidt, H Rübsamen‐Waigmann, ...
EMBO molecular medicine 1 (1), 37-49, 2009
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ
P Sass, M Josten, K Famulla, G Schiffer, HG Sahl, L Hamoen, ...
Proceedings of the National Academy of Sciences 108 (42), 17474-17479, 2011
Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism?
H Brötz, G Bierbaum, A Markus, E Molitor, HG Sahl
Antimicrobial Agents and Chemotherapy 39 (3), 714-719, 1995
The microbiome-shaping roles of bacteriocins
S Heilbronner, B Krismer, H Brötz-Oesterhelt, A Peschel
Nature Reviews Microbiology 19 (11), 726-739, 2021
New insights into the mechanism of action of lantibiotics—diverse biological effects by binding to the same molecular target
H Brötz, HG Sahl
Journal of Antimicrobial Chemotherapy 46 (1), 1-6, 2000
How many modes of action should an antibiotic have?
H Brötz-Oesterhelt, NA Brunner
Current opinion in pharmacology 8 (5), 564-573, 2008
Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones
H Brötz-Oesterhelt, I Knezevic, S Bartel, T Lampe, U Warnecke-Eberz, ...
Journal of Biological Chemistry 278 (41), 39435-39442, 2003
Postgenomic strategies in antibacterial drug discovery
H Brötz-Oesterhelt, P Sass
Future microbiology 5 (10), 1553-1579, 2010
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control
M Gersch, K Famulla, M Dahmen, C Göbl, I Malik, K Richter, VS Korotkov, ...
Nature communications 6 (1), 6320, 2015
Identification of novel essential Escherichia coli genes conserved among pathogenic bacteria
C Freiberg, B Wieland, F Spaltmann, K Ehlert, H Brotz, H Labischinski
Journal of molecular microbiology and biotechnology 3 (3), 483-489, 2001
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