Mary Mohrin
Mary Mohrin
Principal Scientist / Lab Head, Genentech
Verified email at
Cited by
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Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
M Mohrin, E Bourke, D Alexander, MR Warr, K Barry-Holson, MM Le Beau, ...
Cell stem cell 7 (2), 174-185, 2010
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
J Flach, ST Bakker, M Mohrin, PC Conroy, EM Pietras, D Reynaud, ...
Nature 512 (7513), 198-202, 2014
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
M Mohrin, J Shin, Y Liu, K Brown, H Luo, Y Xi, CM Haynes, D Chen
Science 347 (6228), 1374-1377, 2015
SIRT3 reverses aging-associated degeneration
K Brown, S Xie, X Qiu, M Mohrin, J Shin, Y Liu, D Zhang, DT Scadden, ...
Cell reports 3 (2), 319-327, 2013
DNA-damage response in tissue-specific and cancer stem cells
C Blanpain, M Mohrin, PA Sotiropoulou, E Passegué
Cell stem cell 8 (1), 16-29, 2011
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease
J Shin, M He, Y Liu, S Paredes, L Villanova, K Brown, X Qiu, N Nabavi, ...
Cell reports 5 (3), 654-665, 2013
Mitochondrial stress-initiated aberrant activation of the NLRP3 inflammasome regulates the functional deterioration of hematopoietic stem cell aging
H Luo, WC Mu, R Karki, HH Chiang, M Mohrin, JJ Shin, R Ohkubo, K Ito, ...
Cell reports 26 (4), 945-954. e4, 2019
The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence
M Mohrin, A Widjaja, Y Liu, H Luo, D Chen
Aging Cell 17 (3), e12756, 2018
The mitochondrial metabolic checkpoint and aging of hematopoietic stem cells
M Mohrin, D Chen
Current opinion in hematology 23 (4), 318, 2016
Sirtuins, tissue maintenance, and tumorigenesis
M Mohrin, D Chen
Genes & Cancer 4 (3-4), 76-81, 2013
Reversing stem cell aging
J Shin, M Mohrin, D Chen
Oncotarget 6 (17), 14723, 2015
Mito–managing ROS & redox to reboot the immune system: tapping mitochondria & redox management to extend the reach of hematopoietic stem cell transplantation
M Mohrin
Free Radical Biology and Medicine 165, 38-53, 2021
Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis via restraint of mesenchymal stromal cells
M Mohrin, J Liu, J Zavala‐Solorio, S Bhargava, J Maxwell Trumble, A Brito, ...
Aging Cell 20 (3), e13313, 2021
Exploring human skin aging at the single-cell level
M Mohrin, H Jasper
Developmental Cell 56 (3), 253-254, 2021
Pharmacological inhibition of longevity regulator PAPP-A restrains mesenchymal stromal cell activity
M Mohrin, J Liu, J Zavala-Solorio, S Bhargava, JM Trumble, A Brito, D Hu, ...
bioRxiv, 2020.02. 05.936310, 2020
DNA damage response and DNA repair during hematopoietic differentiation and development
M Mohrin
University of California, San Francisco, 2011
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