Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides BF Cravatt, DK Giang, SP Mayfield, DL Boger, RA Lerner, NB Gilula Nature 384 (6604), 83-87, 1996 | 2595 | 1996 |
Quantitative reactivity profiling predicts functional cysteines in proteomes E Weerapana, C Wang, GM Simon, F Richter, S Khare, MBD Dillon, ... Nature 468 (7325), 790-795, 2010 | 1647 | 2010 |
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase BF Cravatt, K Demarest, MP Patricelli, MH Bracey, DK Giang, BR Martin, ... Proceedings of the National Academy of Sciences 98 (16), 9371-9376, 2001 | 1532 | 2001 |
Activity-based protein profiling: from enzyme chemistry to proteomic chemistry BF Cravatt, AT Wright, JW Kozarich Annu. Rev. Biochem. 77 (1), 383-414, 2008 | 1408 | 2008 |
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol JL Blankman, GM Simon, BF Cravatt Chemistry & biology 14 (12), 1347-1356, 2007 | 1361 | 2007 |
Activity-based protein profiling: the serine hydrolases Y Liu, MP Patricelli, BF Cravatt Proceedings of the National Academy of Sciences 96 (26), 14694-14699, 1999 | 1342 | 1999 |
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines LJ Macpherson, AE Dubin, MJ Evans, F Marr, PG Schultz, BF Cravatt, ... Nature 445 (7127), 541-545, 2007 | 1311 | 2007 |
Activity-based protein profiling in vivo using a copper (I)-catalyzed azide-alkyne [3+ 2] cycloaddition AE Speers, GC Adam, BF Cravatt Journal of the American Chemical Society 125 (16), 4686-4687, 2003 | 1301 | 2003 |
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis DK Nomura, JZ Long, S Niessen, HS Hoover, SW Ng, BF Cravatt Cell 140 (1), 49-61, 2010 | 1095 | 2010 |
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects JZ Long, W Li, L Booker, JJ Burston, SG Kinsey, JE Schlosburg, FJ Pavón, ... Nature chemical biology 5 (1), 37-44, 2009 | 1047 | 2009 |
Profiling enzyme activities in vivo using click chemistry methods AE Speers, BF Cravatt Chemistry & biology 11 (4), 535-546, 2004 | 1040 | 2004 |
The biological impact of mass-spectrometry-based proteomics BF Cravatt, GM Simon, JR Yates Iii Nature 450 (7172), 991-1000, 2007 | 873 | 2007 |
How many human proteoforms are there? R Aebersold, JN Agar, IJ Amster, MS Baker, CR Bertozzi, ES Boja, ... Nature chemical biology 14 (3), 206-214, 2018 | 841 | 2018 |
Structure and function of fatty acid amide hydrolase MK McKinney, BF Cravatt Annu. Rev. Biochem. 74 (1), 411-432, 2005 | 795 | 2005 |
Chemical characterization of a family of brain lipids that induce sleep BF Cravatt, O Prospero-Garcia, G Siuzdak, NB Gilula, SJ Henriksen, ... Science 268 (5216), 1506-1509, 1995 | 784 | 1995 |
Proteome-wide covalent ligand discovery in native biological systems KM Backus, BE Correia, KM Lum, S Forli, BD Horning, GE González-Páez, ... Nature 534 (7608), 570-574, 2016 | 776 | 2016 |
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation DK Nomura, BE Morrison, JL Blankman, JZ Long, SG Kinsey, ... Science 334 (6057), 809-813, 2011 | 766 | 2011 |
Mechanism-based profiling of enzyme families MJ Evans, BF Cravatt Chemical reviews 106 (8), 3279-3301, 2006 | 720 | 2006 |
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system JE Schlosburg, JL Blankman, JZ Long, DK Nomura, B Pan, SG Kinsey, ... Nature neuroscience 13 (9), 1113-1119, 2010 | 696 | 2010 |
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system K Ahn, MK McKinney, BF Cravatt Chemical reviews 108 (5), 1687-1707, 2008 | 645 | 2008 |