Wenyi Wei
Wenyi Wei
Professor, Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Verified email at
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Bypass of Senescence After Disruption of p21CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
JP Brown, W Wei, JM Sedivy
Science 277 (5327), 831-834, 1997
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
CM Counter, WC Hahn, W Wei, SD Caddle, RL Beijersbergen, ...
Proceedings of the National Academy of Sciences 95 (25), 14723-14728, 1998
Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance
J Zhang, X Bu, H Wang, Y Zhu, Y Geng, NT Nihira, Y Tan, Y Ci, F Wu, ...
Nature 553 (7686), 91-95, 2018
SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
H Inuzuka, S Shaik, I Onoyama, D Gao, A Tseng, RS Maser, B Zhai, ...
Nature 471 (7336), 104-109, 2011
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer
S Lee, E Nakamura, H Yang, W Wei, MS Linggi, MP Sajan, RV Farese, ...
Cancer cell 8 (2), 155-167, 2005
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
W Wei, NG Ayad, Y Wan, GJ Zhang, MW Kirschner, WG Kaelin Jr
Nature 428 (6979), 194-198, 2004
Roles of F-box proteins in cancer
Z Wang, P Liu, H Inuzuka, W Wei
Nature reviews Cancer 14 (4), 233-247, 2014
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
W Wei, J Jin, S Schlisio, JW Harper, WG Kaelin
Cancer cell 8 (1), 25-33, 2005
The role of ubiquitination in tumorigenesis and targeted drug discovery
L Deng, T Meng, L Chen, W Wei, P Wang
Signal transduction and targeted therapy 5 (1), 11, 2020
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
CH Chan, CF Li, WL Yang, Y Gao, SW Lee, Z Feng, HY Huang, KKC Tsai, ...
Cell 149 (5), 1098-1111, 2012
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
P Liu, W Gan, YR Chin, K Ogura, J Guo, J Zhang, B Wang, J Blenis, ...
Cancer discovery 5 (11), 1194-1209, 2015
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
P Liu, M Begley, W Michowski, H Inuzuka, M Ginzberg, D Gao, P Tsou, ...
Nature 508 (7497), 541-545, 2014
Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin
Z Han, W Wei, S Dunaway, JW Darnowski, P Calabresi, J Sedivy, ...
Journal of Biological Chemistry 277 (19), 17154-17160, 2002
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function
A Papa, L Wan, M Bonora, L Salmena, MS Song, RM Hobbs, A Lunardi, ...
Cell 157 (3), 595-610, 2014
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
P Liu, W Gan, H Inuzuka, AS Lazorchak, D Gao, O Arojo, D Liu, L Wan, ...
Nature cell biology 15 (11), 1340-1350, 2013
Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
X Dai, W Gan, X Li, S Wang, W Zhang, L Huang, S Liu, Q Zhong, J Guo, ...
Nature medicine 23 (9), 1063-1071, 2017
Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts
W Wei, RM Hemmer, JM Sedivy
Molecular and cellular biology 21 (20), 6748-6757, 2001
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
D Gao, H Inuzuka, A Tseng, RY Chin, A Toker, W Wei
Nature cell biology 11 (4), 397-408, 2009
Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase
Z Wang, N Bhattacharya, PF Mixter, W Wei, J Sedivy, NS Magnuson
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1593 (1), 45-55, 2002
mTOR drives its own activation via SCFβTrCP-dependent degradation of the mTOR inhibitor DEPTOR
D Gao, H Inuzuka, MKM Tan, H Fukushima, JW Locasale, P Liu, L Wan, ...
Molecular cell 44 (2), 290-303, 2011
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