| Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer KD Proffitt, B Madan, Z Ke, V Pendharkar, L Ding, MA Lee, RN Hannoush, ... Cancer research 73 (2), 502-507, 2013 | 404 | 2013 |
| Wnt addiction of genetically defined cancers reversed by PORCN inhibition B Madan, Z Ke, N Harmston, SY Ho, AO Frois, J Alam, DA Jeyaraj, ... Oncogene 35 (17), 2197-2207, 2016 | 333 | 2016 |
| Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice W Xiang, Z Ke, Y Zhang, G Ho‐Yuet Cheng, ID Irwan, KN Sulochana, ... Journal of cellular and molecular medicine 15 (2), 359-374, 2011 | 90 | 2011 |
| Cathepsin S is aberrantly overexpressed in human hepatocellular carcinoma J Xu, D Li, Z Ke, R Liu, G Maubach, L Zhuo Molecular medicine reports 2 (5), 713-718, 2009 | 51 | 2009 |
| ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice N Rao, Z Ke, H Liu, CJ Ho, S Kumar, W Xiang, Y Zhu, R Ge International journal of cancer 133 (2), 294-306, 2013 | 50 | 2013 |
| Discovery and optimization of a porcupine inhibitor AJ Duraiswamy, MA Lee, B Madan, SH Ang, ESW Tan, WWV Cheong, ... Journal of medicinal chemistry 58 (15), 5889-5899, 2015 | 45 | 2015 |
| Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment Z Ke, I Kondrichin, Z Gong, V Korzh Molecular and Cellular Neuroscience 37 (2), 388-401, 2008 | 42 | 2008 |
| Scaffold hopping and optimization of maleimide based porcupine inhibitors SY Ho, J Alam, DA Jeyaraj, W Wang, GR Lin, SH Ang, ESW Tan, MA Lee, ... Journal of Medicinal Chemistry 60 (15), 6678-6692, 2017 | 29 | 2017 |
| Discovery of irreversible inhibitors targeting histone methyltransferase, SMYD3 C Huang, SS Liew, GR Lin, A Poulsen, MJY Ang, BCS Chia, SY Chew, ... ACS Medicinal Chemistry Letters 10 (6), 978-984, 2019 | 26 | 2019 |
| NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition B Madan, Z Ke, ZD Lei, FA Oliver, M Oshima, MA Lee, S Rozen, ... Oncotarget 7 (11), 12386, 2016 | 26 | 2016 |
| Expression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development Z Ke, A Emelyanov, SES Lim, V Korzh, Z Gong Developmental dynamics: an official publication of the American Association …, 2005 | 25 | 2005 |
| Metal-free imidazolium salts inhibit the growth of hepatocellular carcinoma in a mouse model B Gopalan, Z Ke, C Zhang, Y Kng, NAM Suhaimi, SN Riduan, Y Zhang, ... Laboratory investigation 91 (5), 744-751, 2011 | 20 | 2011 |
| Pharmacophore model for Wnt/Porcupine inhibitors and its use in drug design A Poulsen, SY Ho, W Wang, J Alam, DA Jeyaraj, SH Ang, ESW Tan, ... Journal of Chemical Information and Modeling 55 (7), 1435-1448, 2015 | 19 | 2015 |
| Therapeutic effect of a multi-targeted imidazolium compound in hepatocellular carcinoma B Gopalan, K Narayanan, Z Ke, T Lu, Y Zhang, L Zhuo Biomaterials 35 (26), 7479-7487, 2014 | 17 | 2014 |
| Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors PS Ng, K Foo, S Sim, G Wang, C Huang, LH Tan, A Poulsen, B Liu, ... Bioorganic & Medicinal Chemistry 49, 116437, 2021 | 10 | 2021 |
| An orally available small imidazolium salt ameliorates inflammation and fibrosis in a murine model of cholestasis Z Ding, Y Kng, H Yang, Z Ke, L Zhuo Laboratory investigation 91 (5), 752-763, 2011 | 10 | 2011 |
| Imidazolium Salt (DBZIM) Reduces Gliosis in Mice Treated with Neurotoxicant 2′‐CH3‐MPTP G Ho, S Kumar, Z Ke, HHN Chan, NAM Suhaimi, YL Kng, Y Zhang, ... CNS neuroscience & therapeutics 17 (3), 148-157, 2011 | 7 | 2011 |
| Method for treating fibrosis and cancer with imidazolium and imidazolinium compounds L Zhuo, C Zhang, Y Zhang, JY Ying, B Gopalan, Z Ke, Z Ding US Patent 9,072,729, 2015 | 3 | 2015 |
| Method for treating fibrosis and cancer with imidazolium and imidazolinium compounds L Zhuo, C Zhang, Y Zhang, JY Ying, B Gopalan, Z Ke, Z Ding | 3 | 2009 |
| Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer J Anantharajan, QW Tan, J Fulwood, W Sifang, Q Huang, HQ Ng, X Koh, ... Biochemical and Biophysical Research Communications 689, 149238, 2023 | 2 | 2023 |
