Donald P. McDonnell
Donald P. McDonnell
Duke University School of Medicine
Verified email at - Homepage
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The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and …
JM Hall, DP McDonnell
Endocrinology 140 (12), 5566-5578, 1999
Cloning and expression of full-length cDNA encoding human vitamin D receptor.
AR Baker, DP McDonnell, M Hughes, TM Crisp, DJ Mangelsdorf, ...
Proceedings of the National Academy of Sciences 85 (10), 3294-3298, 1988
Human progesterone receptor A form is a cell-and promoter-specific repressor of human progesterone receptor B function.
E Vegeto, MM Shahbaz, DX Wen, ME Goldman, BW O'Malley, ...
Molecular endocrinology 7 (10), 1244-1255, 1993
Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.
MT Tzukerman, A Esty, D Santiso-Mere, P Danielian, MG Parker, RB Stein, ...
Molecular endocrinology 8 (1), 21-30, 1994
Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay
KW Gaido, LS Leonard, S Lovell, JC Gould, D Babaı̈, CJ Portier, ...
Toxicology and applied pharmacology 143 (1), 205-212, 1997
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology
ER Nelson, SE Wardell, JS Jasper, S Park, S Suchindran, MK Howe, ...
Science 342 (6162), 1094-1098, 2013
Connections and regulation of the human estrogen receptor
DP McDonnell, JD Norris
Science 296 (5573), 1642-1644, 2002
Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.
DP McDonnell, DL Clemm, T Hermann, ME Goldman, JW Pike
Molecular endocrinology 9 (6), 659-669, 1995
Molecular cloning of complementary DNA encoding the avian receptor for vitamin D
DP McDonnell, DJ Mangelsdorf, JW Pike, MR Haussler, BW O'Malley
Science 235 (4793), 1214-1217, 1987
Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol
JC Gould, LS Leonard, SC Maness, BL Wagner, K Conner, T Zacharewski, ...
Molecular and cellular endocrinology 142 (1-2), 203-214, 1998
Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells
JP Chute, GG Muramoto, J Whitesides, M Colvin, R Safi, NJ Chao, ...
Proceedings of the National Academy of Sciences 103 (31), 11707-11712, 2006
The human estrogen receptor-α is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators
AL Wijayaratne, DP McDonnell
Journal of Biological Chemistry 276 (38), 35684-35692, 2001
Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β
LA Paige, DJ Christensen, H Grøn, JD Norris, EB Gottlin, KM Padilla, ...
Proceedings of the National Academy of Sciences 96 (7), 3999-4004, 1999
Variant human breast tumor estrogen receptor with constitutive transcriptional activity
SAW Fuqua, SD Fitzgerald, GC Chamness, AK Tandon, DP McDonnell, ...
Cancer Research 51 (1), 105-109, 1991
International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen …
NZ Lu, SE Wardell, KL Burnstein, D Defranco, PJ Fuller, V Giguere, ...
Pharmacological reviews 58 (4), 782-797, 2006
Peptide antagonists of the human estrogen receptor
JD Norris, LA Paige, DJ Christensen, CY Chang, MR Huacani, D Fan, ...
Science 285 (5428), 744-746, 1999
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor
E Vegeto, GF Allan, WT Schrader, MJ Tsai, DP McDonnell, BW O'Malley
Cell 69 (4), 703-713, 1992
Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors α and β
C Chang, JD Norris, H Grøn, LA Paige, PT Hamilton, DJ Kenan, ...
Molecular and cellular biology, 1999
Evaluation of a recombinant yeast cell estrogen screening assay.
NG Coldham, M Dave, S Sivapathasundaram, DP McDonnell, C Connor, ...
Environmental health perspectives 105 (7), 734-742, 1997
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium
T Improta-Brears, AR Whorton, F Codazzi, JD York, T Meyer, ...
Proceedings of the National Academy of Sciences 96 (8), 4686-4691, 1999
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