| Emerging principles in protease-based drug discovery M Drag, GS Salvesen Nature reviews Drug discovery 9 (9), 690-701, 2010 | 669 | 2010 |
| Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design W Rut, Z Lv, M Zmudzinski, S Patchett, D Nayak, SJ Snipas, F El Oualid, ... Science advances 6 (42), eabd4596, 2020 | 363 | 2020 |
| SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging W Rut, K Groborz, L Zhang, X Sun, M Zmudzinski, B Pawlik, X Wang, ... Nature chemical biology 17 (2), 222-228, 2021 | 266 | 2021 |
| FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity C Pop, A Oberst, M Drag, BJ Van Raam, SJ Riedl, DR Green, ... Biochemical Journal 433 (3), 447-457, 2011 | 262 | 2011 |
| Caspase substrates and inhibitors M Poręba, A Stróżyk, GS Salvesen, M Drąg Cold Spring Harbor perspectives in biology 5 (8), a008680, 2013 | 233 | 2013 |
| A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis J Walters, C Pop, FL Scott, M Drag, P Swartz, C Mattos, GS Salvesen, ... Biochemical Journal 424 (3), 335-345, 2009 | 223 | 2009 |
| Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs J Mikolajczyk, M Drag, M Békés, JT Cao, Z Ronai, GS Salvesen Journal of Biological Chemistry 282 (36), 26217-26224, 2007 | 201 | 2007 |
| SUMO-mediated regulation of NLRP3 modulates inflammasome activity R Barry, SW John, G Liccardi, T Tenev, I Jaco, CH Chen, J Choi, ... Nature communications 9 (1), 3001, 2018 | 197 | 2018 |
| The strategies to support the COVID-19 vaccination with evidence-based communication and tackling misinformation P Rzymski, L Borkowski, M Drąg, R Flisiak, J Jemielity, J Krajewski, ... Vaccines 9 (2), 109, 2021 | 180 | 2021 |
| Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling P Kasperkiewicz, M Poreba, SJ Snipas, H Parker, CC Winterbourn, ... Proceedings of the National Academy of Sciences 111 (7), 2518-2523, 2014 | 171 | 2014 |
| Metallo-aminopeptidase inhibitors A Mucha, M Drag, JP Dalton, P Kafarski Biochimie 92 (11), 1509-1529, 2010 | 157 | 2010 |
| Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials TS Skinner-Adams, CM Stack, KR Trenholme, CL Brown, J Grembecka, ... Trends in Biochemical Sciences 35 (1), 53-61, 2010 | 155 | 2010 |
| DeSUMOylating enzymes—SENPs M Drag, GS Salvesen IUBMB life 60 (11), 734-742, 2008 | 144 | 2008 |
| Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug … M Drag, P Surowiak, M Drag-Zalesinska, M Dietel, H Lage, J Oleksyszyn Molecules 14 (4), 1639-1651, 2009 | 127 | 2009 |
| Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells M Drag-Zalesinska, J Kulbacka, J Saczko, T Wysocka, M Zabel, ... Bioorganic & medicinal chemistry letters 19 (16), 4814-4817, 2009 | 126 | 2009 |
| Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides E Zervoudi, A Papakyriakou, D Georgiadou, I Evnouchidou, A Gajda, ... Biochemical Journal 435 (2), 411-420, 2011 | 122 | 2011 |
| Distribution and paralogue specificity of mammalian deSUMOylating enzymes N Kolli, J Mikolajczyk, M Drag, D Mukhopadhyay, N Moffatt, M Dasso, ... Biochemical Journal 430 (2), 335-344, 2010 | 121 | 2010 |
| Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design W Rut, Z Lv, M Zmudzinski, S Patchett, D Nayak, SJ Snipas, F El Oualid, ... biorxiv, 2020.04. 29.068890, 2020 | 115 | 2020 |
| Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors M Drag, M Bogyo, JA Ellman, GS Salvesen Journal of Biological Chemistry 285 (5), 3310-3318, 2010 | 112 | 2010 |
| Mechanism and specificity of the human paracaspase MALT1 J Hachmann, SJ Snipas, BJ van Raam, EM Cancino, EJ Houlihan, ... Biochemical Journal 443 (1), 287-295, 2012 | 109 | 2012 |
Guy SalvesenProfessor, Sanford-Burnham Medical Research InstituteVerified email at sbpdiscovery.org
