| Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo WE Dowdle, B Nyfeler, J Nagel, RA Elling, S Liu, E Triantafellow, ... Nature cell biology 16 (11), 1069-1079, 2014 | 699 | 2014 |
| Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms KC Corbit, AE Shyer, WE Dowdle, J Gaulden, V Singla, JF Reiter Nature cell biology 10 (1), 70-76, 2008 | 611 | 2008 |
| ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events S Shin, CA Dimitri, SO Yoon, W Dowdle, J Blenis Molecular cell 38 (1), 114-127, 2010 | 334 | 2010 |
| Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS/FTD MY Fang, S Markmiller, AQ Vu, A Javaherian, WE Dowdle, P Jolivet, ... Neuron 103 (5), 802-819. e11, 2019 | 214 | 2019 |
| Disruption of a ciliary B9 protein complex causes Meckel syndrome WE Dowdle, JF Robinson, A Kneist, MS Sirerol-Piquer, SGM Frints, ... The American Journal of Human Genetics 89 (1), 94-110, 2011 | 174 | 2011 |
| Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9 JM Goodwin, WE Dowdle, R DeJesus, Z Wang, P Bergman, M Kobylarz, ... Cell reports 20 (10), 2341-2356, 2017 | 164 | 2017 |
| Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo CA Dimitri, W Dowdle, JP MacKeigan, J Blenis, LO Murphy Current Biology 15 (14), 1319-1324, 2005 | 135 | 2005 |
| TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone EC Roberson, WE Dowdle, A Ozanturk, FR Garcia-Gonzalo, C Li, ... Journal of Cell Biology 209 (1), 129-142, 2015 | 116 | 2015 |
| Role of epidermal primary cilia in the homeostasis of skin and hair follicles MJ Croyle, JM Lehman, AK O'Connor, SY Wong, EB Malarkey, D Iribarne, ... Development 138 (9), 1675-1685, 2011 | 82 | 2011 |
| A high-fat diet regulates gastrin and acid secretion through primary cilia M Saqui-Salces, WE Dowdle, JF Reiter, JL Merchant The FASEB Journal 26 (8), 3127, 2012 | 65 | 2012 |
| Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo A Honda, E Harrington, I Cornella-Taracido, P Furet, MS Knapp, M Glick, ... ACS medicinal chemistry letters 7 (1), 72-76, 2016 | 60 | 2016 |
| Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques X Hu, K White, AG Olroyd, R DeJesus, AA Dominguez, WE Dowdle, ... Nature biotechnology 42 (3), 413-423, 2024 | 49 | 2024 |
| Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice X Hu, K Manner, R DeJesus, K White, C Gattis, P Ngo, C Bandoro, ... Nature Communications 14 (1), 2020, 2023 | 37 | 2023 |
| Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice X Hu, C Gattis, AG Olroyd, AM Friera, K White, C Young, R Basco, ... Science translational medicine 15 (691), eadg5794, 2023 | 35 | 2023 |
| SUPT4H1 depletion leads to a global reduction in RNA A Naguib, T Sandmann, F Yi, RJ Watts, JW Lewcock, WE Dowdle Cell Reports 26 (1), 45-53. e4, 2019 | 20 | 2019 |
| Engineered hypoimmune allogeneic CAR T cells exhibit innate and adaptive immune evasion even after sensitization in humanized mice and retain potent anti-tumor activity X Hu, M Dao, K White, C Gattis, R Clarke, S Landry, R Basco, E Tham, ... Blood 138, 1690, 2021 | 6 | 2021 |
| Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms (vol 10, pg 70, 2008) KC Corbit, AE Shyer, WE Dowdle, J Gaulden, V Singla, MH Chen, ... Nature cell biology 10 (4), 497-497, 2008 | 5 | 2008 |
| Abstract LB144: overexpression of CD47 protects hypoimmune CAR T cells from innate immune cell killing X Hu, M Dao, K White, R Clarke, S Landry, R Basco, C Gattis, E Tham, ... Cancer Research 81 (13_Supplement), LB144-LB144, 2021 | 4 | 2021 |
| DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response E Yulyaningsih, JH Suh, MH Fanok, R Chau, H Solanoy, R Takahashi, ... bioRxiv, 2023.08. 21.554203, 2023 | 3 | 2023 |
| Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases RA Craig, J De Vicente, AA Estrada, JA Feng, KW Lexa, MJ Canet, ... Journal of Medicinal Chemistry 67 (7), 5758-5782, 2024 | 2 | 2024 |
