Leo E. Otterbein
Leo E. Otterbein
Professor, Harvard Medical School
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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
LE Otterbein, FH Bach, J Alam, M Soares, H Tao Lu, M Wysk, RJ Davis, ...
Nature medicine 6 (4), 422-428, 2000
The therapeutic potential of carbon monoxide
R Motterlini, LE Otterbein
Nature reviews Drug discovery 9 (9), 728-743, 2010
Heme oxygenase-1: unleashing the protective properties of heme
LE Otterbein, MP Soares, K Yamashita, FH Bach
Trends in immunology 24 (8), 449-455, 2003
Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis
S Brouard, LE Otterbein, J Anrather, E Tobiasch, FH Bach, AMK Choi, ...
The Journal of experimental medicine 192 (7), 1015-1026, 2000
Heme oxygenase: colors of defense against cellular stress
LE Otterbein, AMK Choi
American Journal of Physiology-Lung Cellular and Molecular Physiology 279 (6 …, 2000
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
LE Otterbein, BS Zuckerbraun, M Haga, F Liu, R Song, A Usheva, ...
Nature medicine 9 (2), 183-190, 2003
Heme oxygenase/carbon monoxide signaling path-ways: Regulation and functional significance
SW Ryter, LE Otterbein, D Morse, AMK Choi
Oxygen/Nitrogen Radicals: Cell Injury and Disease, 249-263, 2002
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
A Haschemi, P Kosma, L Gille, CR Evans, CF Burant, P Starkl, B Knapp, ...
Cell metabolism 15 (6), 813-826, 2012
Carbon monoxide provides protection against hyperoxic lung injury
LE Otterbein, LL Mantell, AMK Choi
American Journal of Physiology-Lung Cellular and Molecular Physiology 276 (4 …, 1999
Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury
LE Otterbein, JK Kolls, LL Mantell, JL Cook, J Alam, AMK Choi
The Journal of clinical investigation 103 (7), 1047-1054, 1999
Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants
K Sato, J Balla, L Otterbein, RN Smith, S Brouard, Y Lin, E Csizmadia, ...
The Journal of Immunology 166 (6), 4185-4194, 2001
Carbon monoxide in biology and medicine
SW Ryter, LE Otterbein
Bioessays 26 (3), 270-280, 2004
Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1
D Morse, SE Pischke, Z Zhou, RJ Davis, RA Flavell, T Loop, SL Otterbein, ...
Journal of Biological Chemistry 278 (39), 36993-36998, 2003
Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts
I Petrache, LE Otterbein, J Alam, GW Wiegand, AMK Choi
American Journal of Physiology-Lung Cellular and Molecular Physiology 278 (2 …, 2000
Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α
ID Mascanfroni, MC Takenaka, A Yeste, B Patel, Y Wu, JE Kenison, ...
Nature medicine 21 (6), 638-646, 2015
Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1.
L Otterbein, SL Sylvester, AM Choi
American journal of respiratory cell and molecular biology 13 (5), 595-601, 1995
Autoantibodies in patients with chronic obstructive pulmonary disease
CA Feghali-Bostwick, AS Gadgil, LE Otterbein, JM Pilewski, MW Stoner, ...
American journal of respiratory and critical care medicine 177 (2), 156-163, 2008
Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species
BS Zuckerbraun, BY Chin, M Bilban, JC d'Avila, J Rao, TR Billiar, ...
The FASEB Journal 21 (4), 1099-1106, 2007
Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3
X Zhang, P Shan, LE Otterbein, J Alam, RA Flavell, RJ Davis, AMK Choi, ...
Journal of Biological Chemistry 278 (2), 1248-1258, 2003
Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth
B Wegiel, D Gallo, E Csizmadia, C Harris, J Belcher, GM Vercellotti, ...
Cancer research 73 (23), 7009-7021, 2013
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