| Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ... Cell 173 (3), 677-692. e20, 2018 | 464 | 2018 |
| Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104 SN Gates, AL Yokom, JB Lin, ME Jackrel, AN Rizo, NM Kendsersky, ... Science 357 (6348), 273-279, 2017 | 275 | 2017 |
| Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events ME Jackrel, ME DeSantis, BA Martinez, LM Castellano, RM Stewart, ... Cell 156 (1), 170-182, 2014 | 255 | 2014 |
| Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients ME DeSantis, EH Leung, EA Sweeny, ME Jackrel, M Cushman-Nick, ... Cell 151 (4), 778-793, 2012 | 202 | 2012 |
| FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination K Yasuda, SF Clatterbuck-Soper, ME Jackrel, J Shorter, S Mili Journal of Cell Biology 216 (4), 1015-1034, 2017 | 125 | 2017 |
| Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation AL Yokom, SN Gates, ME Jackrel, KL Mack, M Su, J Shorter, ... Nature structural & molecular biology 23 (9), 830-837, 2016 | 120 | 2016 |
| The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation EA Sweeny, ME Jackrel, MS Go, MA Sochor, BM Razzo, ME DeSantis, ... Molecular cell 57 (5), 836-849, 2015 | 106 | 2015 |
| Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins ME Jackrel, J Shorter Disease models & mechanisms 7 (10), 1175-1184, 2014 | 98 | 2014 |
| Engineering enhanced protein disaggregases for neurodegenerative disease ME Jackrel, J Shorter Prion 9 (2), 90-109, 2015 | 81 | 2015 |
| Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay ME Jackrel, AL Cortajarena, TY Liu, L Regan ACS chemical biology 5 (6), 553-562, 2010 | 63 | 2010 |
| A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing EA Champion, BH Lane, ME Jackrel, L Regan, SJ Baserga Molecular and cellular biology 28 (21), 6547-6556, 2008 | 57 | 2008 |
| Mining disaggregase sequence space to safely counter TDP-43, FUS, and α-synuclein proteotoxicity A Tariq, JB Lin, ME Jackrel, CD Hesketh, PJ Carman, KL Mack, ... Cell reports 28 (8), 2080-2095. e6, 2019 | 49 | 2019 |
| Mechanistic insights into Hsp104 potentiation MP Torrente, E Chuang, MM Noll, ME Jackrel, MS Go, J Shorter Journal of Biological Chemistry 291 (10), 5101-5115, 2016 | 46 | 2016 |
| Redesign of a protein–peptide interaction: characterization and applications ME Jackrel, R Valverde, L Regan Protein Science 18 (4), 762-774, 2009 | 46 | 2009 |
| Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain A Tariq, JB Lin, MM Noll, MP Torrente, KL Mack, OH Murillo, ME Jackrel, ... FEMS Yeast Research 18 (5), foy042, 2018 | 43 | 2018 |
| Disparate mutations confer therapeutic gain of Hsp104 function ME Jackrel, K Yee, A Tariq, AI Chen, J Shorter ACS chemical biology 10 (12), 2672-2679, 2015 | 42 | 2015 |
| Reversing deleterious protein aggregation with re-engineered protein disaggregases ME Jackrel, J Shorter Cell Cycle 13 (9), 1379-1383, 2014 | 42 | 2014 |
| Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma JJ Ryan, ML Sprunger, K Holthaus, J Shorter, ME Jackrel Journal of Biological Chemistry 294 (29), 11286-11296, 2019 | 41 | 2019 |
| Prion-like proteins in phase separation and their link to disease ML Sprunger, ME Jackrel Biomolecules 11 (7), 1014, 2021 | 39 | 2021 |
| Structure of Calcarisporiella thermophila Hsp104 disaggregase that antagonizes diverse proteotoxic misfolding events K Michalska, K Zhang, ZM March, C Hatzos-Skintges, G Pintilie, L Bigelow, ... Structure 27 (3), 449-463. e7, 2019 | 38 | 2019 |
