Raimundo Freire
Raimundo Freire
Hospital Universitario Canarias/FIISC; Instituto Tecn. Biomédicas-Univ. la Laguna
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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
L Macůrek, A Lindqvist, D Lim, MA Lampson, R Klompmaker, R Freire, ...
Nature 455 (7209), 119-123, 2008
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
I Mamely, MATM van Vugt, VAJ Smits, JI Semple, B Lemmens, A Perrakis, ...
Current Biology 16 (19), 1950-1955, 2006
Metalloprotease SPRTN/DVC1 orchestrates replication-coupled DNA-protein crosslink repair
B Vaz, M Popovic, JA Newman, J Fielden, H Aitkenhead, S Halder, ...
Molecular cell 64 (4), 704-719, 2016
Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features
D Lessel, B Vaz, S Halder, PJ Lockhart, I Marinovic-Terzic, ...
Nature genetics 46 (11), 1239-1244, 2014
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease
R Domínguez-Kelly, Y Martín, S Koundrioukoff, ME Tanenbaum, ...
Journal of Cell Biology 194 (4), 567-579, 2011
The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability
M Petkovic, T Dietschy, R Freire, R Jiao, I Stagljar
Journal of cell science 118 (18), 4261-4269, 2005
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding
J Hein, S Boichuk, J Wu, Y Cheng, R Freire, PS Jat, TM Roberts, ...
Journal of virology 83 (1), 117-127, 2009
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase β and increases its DNA substrate utilisation efficiency: implications for DNA repair
M Toueille, N El-Andaloussi, I Frouin, R Freire, D Funk, I Shevelev, ...
Nucleic acids research 32 (11), 3316-3324, 2004
OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance
U Karunarathna, M Kongsema, S Zona, C Gong, E Cabrera, AR Gomes, ...
Oncogene 35 (11), 1433-1444, 2016
Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1
M Cotsiki, RL Lock, Y Cheng, GL Williams, J Zhao, D Perera, R Freire, ...
Proceedings of the National Academy of Sciences 101 (4), 947-952, 2004
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance
P Khongkow, U Karunarathna, M Khongkow, C Gong, AR Gomes, ...
Oncogene 33 (32), 4144-4155, 2014
Direct association of Bloom’s syndrome gene product with the human mismatch repair protein MLH1
G Pedrazzi, C Perrera, H Blaser, P Kuster, G Marra, SL Davies, GH Ryu, ...
Nucleic acids research 29 (21), 4378-4386, 2001
Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection
A Kakarougkas, A Ismail, Y Katsuki, R Freire, A Shibata, PA Jeggo
Nucleic acids research 41 (22), 10298-10311, 2013
Bora and Aurora-A continue to activate Plk1 in mitosis
W Bruinsma, L Macůrek, R Freire, A Lindqvist, RH Medema
Journal of cell science 127 (4), 801-811, 2014
Human and mouse homologs of Schizosaccharomyces pombe rad1+ and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis
R Freire, JR Murguía, M Tarsounas, NF Lowndes, PB Moens, SP Jackson
Genes & development 12 (16), 2560-2573, 1998
The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment
LJ Monteiro, P Khongkow, M Kongsema, JR Morris, C Man, D Weekes, ...
Oncogene 32 (39), 4634-4645, 2013
Expression and nuclear localization of BLM, a chromosome stability protein mutated in Bloom’s syndrome, suggest a role in recombination during meiotic prophase
PB Moens, R Freire, M Tarsounas, B Spyropoulos, SP Jackson
Journal of Cell Science 113 (4), 663-672, 2000
Opposing roles for 53BP1 during homologous recombination
A Kakarougkas, A Ismail, K Klement, AA Goodarzi, S Conrad, R Freire, ...
Nucleic acids research 41 (21), 9719-9731, 2013
The association of ATR protein with mouse meiotic chromosome cores
PB Moens, M Tarsounas, T Morita, T Habu, ST Rottinghaus, R Freire, ...
Chromosoma 108, 95-102, 1999
TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint
D Perera, L Perez-Hidalgo, PB Moens, K Reini, N Lakin, JE Syväoja, ...
Molecular biology of the cell 15 (4), 1568-1579, 2004
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