Jeffrey Savas
Jeffrey Savas
Assistant Professor of Neurology, Northwestern University Feinberg School of Medicine
Verified email at - Homepage
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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
CN Parkhurst, G Yang, I Ninan, JN Savas, JR Yates, JJ Lafaille, ...
Cell 155 (7), 1596-1609, 2013
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
LF Burbulla, P Song, JR Mazzulli, E Zampese, YC Wong, S Jeon, ...
Science 357 (6357), 1255-1261, 2017
Identification of long-lived proteins reveals exceptional stability of essential cellular structures
BH Toyama, JN Savas, SK Park, MS Harris, NT Ingolia, JR Yates, ...
Cell 154 (5), 971-982, 2013
Acetylation targets mutant huntingtin to autophagosomes for degradation
H Jeong, F Then, TJ Melia, JR Mazzulli, L Cui, JN Savas, C Voisine, ...
Cell 137 (1), 60-72, 2009
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
K Brennand, JN Savas, Y Kim, N Tran, A Simone, K Hashimoto-Torii, ...
Molecular psychiatry 20 (3), 361-368, 2015
LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation
J De Wit, E Sylwestrak, ML O'Sullivan, S Otto, K Tiglio, JN Savas, ...
Neuron 64 (6), 799-806, 2009
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
H Jeong, DE Cohen, L Cui, A Supinski, JN Savas, JR Mazzulli, ...
Nature medicine 18 (1), 159-165, 2012
Extremely long-lived nuclear pore proteins in the rat brain
JN Savas, BH Toyama, T Xu, JR Yates III, MW Hetzer
Science 335 (6071), 942-942, 2012
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission
HC Rice, D De Malmazet, A Schreurs, S Frere, I Van Molle, AN Volkov, ...
Science 363 (6423), eaao4827, 2019
FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development
ML O'Sullivan, J de Wit, JN Savas, D Comoletti, S Otto-Hitt, JR Yates, ...
Neuron 73 (5), 903-910, 2012
Progressive accumulation of amyloid‐β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations …
E Pham, L Crews, K Ubhi, L Hansen, A Adame, A Cartier, D Salmon, ...
The FEBS journal 277 (14), 3051-3067, 2010
Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L
NF Shanks, JN Savas, T Maruo, O Cais, A Hirao, S Oe, A Ghosh, Y Noda, ...
Cell reports 1 (6), 590-598, 2012
Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies
JN Savas, A Makusky, S Ottosen, D Baillat, F Then, D Krainc, ...
Proceedings of the National Academy of Sciences 105 (31), 10820-10825, 2008
Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development
J de Wit, ML O’Sullivan, JN Savas, G Condomitti, MC Caccese, ...
Neuron 79 (4), 696-711, 2013
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy
L Wang, Z Zhao, PA Ozark, D Fantini, SA Marshall, EJ Rendleman, ...
Nature medicine 24 (6), 758-769, 2018
Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis
BP Culver, JN Savas, SK Park, JH Choi, S Zheng, SO Zeitlin, JR Yates, ...
Journal of Biological Chemistry 287 (26), 21599-21614, 2012
Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p. Q575E)
J Park, J Yang, AT Wenzel, A Ramachandran, WJ Lee, JC Daniels, J Kim, ...
Blood, The Journal of the American Society of Hematology 130 (12), 1430-1440, 2017
The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation
R Yonashiro, EB Tahara, MH Bengtson, M Khokhrina, H Lorenz, KC Chen, ...
Elife 5, e11794, 2016
A role for huntington disease protein in dendritic RNA granules
JN Savas, B Ma, K Deinhardt, BP Culver, S Restituito, L Wu, JG Belasco, ...
Journal of biological chemistry 285 (17), 13142-13153, 2010
Microarray analysis of the hyperthermophilic archaeon Pyrococcus furiosus exposed to gamma irradiation
E Williams, TM Lowe, J Savas, J DiRuggiero
Extremophiles 11, 19-29, 2007
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